Serum alpha-tocopherol concentrations and risk of type 1 diabetes mellitus: a cohort study in siblings of affected children.

Animal models have indicated that alpha-tocopherol may protect against type 1 diabetes mellitus (DM1). Epidemiological data on the subject are scarce. The objective of this study was to evaluate the association of serum alpha-tocopherol concentration and risk of DM1 in a cohort of initially non-diabetic siblings of children affected by DM1 (n = 722). We used two study designs: 1) Siblings who progressed to DM1 were compared with control siblings who remained negative for DM1-associated autoantibodies in a nested case-control study design. 2) All siblings with DM1-associated autoantibodies were prospectively followed for DM1. In both designs, high concentrations of serum alpha-tocopherol tended to be associated with a lower risk of DM1 (p = 0.08 and 0.09, respectively). Although the results did not reach statistical significance, they support the hypothesis that high alpha-tocopherol levels may protect against DM1.

作 者：

Uusitalo L；Knip M；Kenward MG；Alfthan G；Sundvall J；Aro A；Reunanen A；Akerblom HK；Virtanen SM

刊 名：

Journal of Pediatric Endocrinology & Metabolism 

年，卷(期)：

2005vol.18(no.12) 

分类号：

 

关键词：

alpha-Tocopherol  Serum  Risk  Diabetes Mellitus, Insulin-Dependent  Child  危险  糖尿病, 胰岛素依赖型  儿童

正文语种：

eng 

基金项目：