Therapy insight: neurological complications of prediabetes.

Stroke and peripheral neuropathy are recognized neurological complications of diabetes. Increasing epidemiological evidence also implicates the prediabetic state of impaired glucose tolerance (IGT) as a risk factor for cerebrovascular events and peripheral neuropathy. Data linking IGT to cognitive decline or deficits, however, are less robust. IGT is one component of metabolic syndrome, together with central obesity, hypertension, hypertriglyceridemia and reduced HDL. Each component of metabolic syndrome is an independent risk factor for stroke, but hyperglycemia might be more important than other components in the pathogenesis of neuropathy. Goal-driven diet and exercise regimens, together with pharmacological treatment of hyperlipidemia and hypertension, reduce stroke risk, but the effect of these interventions on neuropathy has not been fully explored.

作 者：

Singleton,JR；Smith,AG

刊 名：

Nature clinical practice. Neurology 

年，卷(期)：

2006vol.2(no.5) 

分类号：

 

关键词：

Cerebrovascular Accident  Cognition Disorders  Diabetic Neuropathies  Humans  认知障碍  糖尿病神经病变  糖尿病前期

正文语种：

eng 

基金项目：