Have we been barking up the wrong tree: can a good night's sleep make us slimmer?

Imagine that you suddenly read in Nature that scientists have discovered a new environmental agent that has an adverse effect on the hypothalamic system for appetite regulation, and makes the affected subjects extremely vulnerable to weight gain when exposed to a high-fat diet, large portion sizes and physical inactivity. The agent was found to cause a desensitising of a number of receptors mediating the satiating effect of leptin, GLP1, CCK and PYY, and by this means it disconnects the brain from most of the communication from the periphery, so that the brain is unable to respond adequately when the gastrointestinal tract, and glycogen and fat stores are all full of nutrients. The agent could be a virus, a pollutant, a trans fatty acid or another environmental factor to which exposure has increased dramatically over the past 60 years, coinciding with the obesity epidemic. Would you be surprised? Or would you feel that we now have a sensible explanation for what is really going on?

作 者：

Astrup,A

刊 名：

International journal of obesity 

年，卷(期)：

2006vol.30(no.7) 

分类号：

 

关键词：

night  Sleep  睡眠

正文语种：

eng 

基金项目：