Emerging roles for protein histidine phosphorylation in cellular signal transduction: lessons from the islet beta-cell.

* Introduction * Protein histidine phosphorylation in prokaryotes and eukaryotes * Identification and characterization of histidine kinases in the pancreatic beta-cell - Stability characteristics of phosphoamino acids - Nucleoside diphosphate kinases - Biochemical characterization of the NDPK in beta-cell subcellular fractions - Characterization of the mitochondrial isoform of NDPK - A membrane-associated histidine kinase phosphorylates the G(beta)-subunit of trimeric G-proteins - A novel histone H4-phosphorylating histidine kinase in islets beta-cells * Regulation of protein histidine phosphorylation in islet beta-cells - Inhibitors of protein histidine phosphorylation - Activators of protein histidine phosphorylation - Activation of histidine kinases by biologically active lipids - Activation of histidine kinases by mastoparan analogues * Functional consequences of protein histidine phosphorylation - Compartmentalized generation of GTP - Regulation of islet endogenous G-proteins - Regulation of smallG-protein function by histidine phosphorylation - Regulation of trimeric G-protein function by histidine phosphorylation - Regulation of the mitochondrial function via protein histidine phosphorylation - Regulation of ion channels - Regulation of isoprenoid metabolism * Protein histidine phosphatases * * Potential defects in histidine phosphorylation in * islets derived from the Goto-Kakizaki rat, a model for type 2 diabetes * Conclusions and future research.

作 者：

Kowluru,A

刊 名：

Journal of Cellular and Molecular Medicine 

年，卷(期)：

2008vol.12(no.5B) 

分类号：

 

关键词：

Histidine  Phosphorylation  Regulation  Proteins  组氨酸  磷酰化  蛋白质类

正文语种：

eng 

基金项目：