The effects of systemic medications on ocular blood flow.

This article reviews the effects of systemic medications and some native vasoactive molecules on ocular blood flow (OBF). Some evidence exists for a positive effect of centrally acting calcium-channel blockers, nitric oxide precursors, adenosine, histamine, estrogens, and ginkgo biloba extract, while evidence for a negative effect on OBF exists for endothelin-1 and indomethacin. Some other molecules appear to have mixed effects, depending on the ocular vascular bed studied or the study protocol. In addition, medically induced changes in systemic blood pressure (BP) have an important impact on OBF, and the direction and magnitude of this effect may depend on the disease status of the patient and of the eye, as well as the absolute level of BP achieved. There are relatively few studies of the effects of systemic medications on OBF in glaucoma patients, and little is known of the long-term impact of such therapies on the preservation of optic nerve structure and function.

作 者：

Lesk,MR；Wajszilber,M；Deschenes,MC

刊 名：

Canadian Journal of Ophthalmology 

年，卷(期)：

2008vol.43(no.3) 

分类号：

 

关键词：

Blood Flow Velocity  Blood Pressure  Eye  Glaucoma, Open-Angle  Humans  Optic Disk  血流速度  血压  眼  青光眼, 开角型  视盘  局部血流  视网膜血管

正文语种：

eng 

基金项目：