How effective is continuous glucose monitoring in intensively treated type 1 diabetes mellitus?

This Practice Point commentary discusses the findings of a multicenter clinical trial conducted by the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group. In the study, 322 individuals aged >/=8 years who were already receiving intensive insulin therapy for type 1 diabetes mellitus were randomly assigned to either a group that performed continuous glucose monitoring (CGM), or to a control group that performed conventional self-monitoring with a blood-glucose meter. At week 26, the between-group difference in the change in HbA(1c) level from baseline varied according to the patient's age. A significantly greater reduction in HbA(1c) level in the CGM group compared with the control group was found in patients aged >or=25 years, but not in those aged 8-14 years or 15-24 years. In patients aged >or=25 years, CGM improved glycemic control without increasing the frequency of hypoglycemia. Motivation, willingness to change diabetes self-care behaviors, and the ability to use CGM effectively are important determinants of whether this technology will improve glycemic control.

作 者：

Wolfsdorf,JI

刊 名：

Nature clinical practice. Endocrinology & metabolism 

年，卷(期)：

2009vol.5(no.3) 

分类号：

 

关键词：

glucose monitor  Diabetes Mellitus, Insulin-Dependent  control  Hemoglobin A  糖尿病, 胰岛素依赖型  血红蛋白A

正文语种：

eng 

基金项目：