Longitudinal study of body cell mass depletion and the inflammatory response in cancer patients.

There is recent evidence that the inflammatory response may be important in the disproportionate loss of body cell mass in cancer patients. To examine this further, 18 male patients with lung or gastrointestinal cancer were studied over a 12-week period. In addition to weight, anthropometry, C-reactive protein (marker of the inflammatory response), albumin, and total body potassium were measured at baseline and 12 weeks. When those patients who lost total body potassium were compared with thosewho had not, there was a significant increase in the baseline and 12-week C-reactive protein concentrations (p < 0.05). The reduction in total body potassium was also associated with a reduction in triceps skinfold thickness (p < 0.05). There were significant correlations between the mean C-reactive protein concentration and the relative (r = -0.846, p < 0.001) and absolute (r = -0.806, p < 0.001) change in total body potassium over the follow-up period. This study demonstrates the association of a chronic inflammatory response with the rate of loss of body cell mass observed in cancer patients.

作 者：

McMillan,DC；Scott,HR；Watson,WS；Preston,T；Milroy,R；McArdle,CS

刊 名：

Nutrition and Cancer 

年，卷(期)：

1998V.31,no.2,1998("") 

分类号：

 

关键词：

Albumins  C-Reactive Protein  Gastrointestinal Neoplasms  Lung Neoplasms  白蛋白类  C反应蛋白质  胃肠肿瘤  肺肿瘤  钾

正文语种：

eng 

基金项目：