Lipotoxicity and glucotoxicity in type 2 diabetes. Effects on development and progression.

Excess fat, excess glucose, or both act on diverse cells and tissues to counteract insulin-mediated glucose uptake, hepatic regulation of glucose output, and insulin secretion. These effects are labeled lipotoxicity and glucotoxicity because, when severe enough, each may contribute to the diabetic state. Lifestyle modifications and certain new pharmacologic agents may be effective in modulating these effects and could prove useful in primary prevention of type 2 diabetes.

作 者：

Sivitz,WI

刊 名：

Postgraduate Medicine 

年，卷(期)：

2001V.109,no.4,2001("") 

分类号：

 

关键词：

Blood Glucose  Diabetes Mellitus, Non-Insulin-Dependent  Hyperlipidemia  血糖  糖尿病, 非胰岛素依赖型  高脂血症  脂类

正文语种：

eng 

基金项目：