The prediction of resting energy expenditure in type 2 diabetes mellitus is improved by factoring for glycemia.

BACKGROUND:: Predictive equations have been reported to overestimate resting energy expenditure (REE) for obese persons. The presence of hyperglycemia results in elevated REE in obese persons with type 2 diabetes, and its effect on the validity of these equations is unknown. OBJECTIVE:: We tested whether (1) indicators of diabetes control were independent associates of REE in type 2 diabetes and (2) their inclusion would improve predictive equations. DESIGN:: A cross-sectional study of 65 (25 men, 40 women) obese type 2 diabetic subjects. Variables measured were: REE by ventilated-hood indirect calorimetry, body composition by bioimpedance analysis, body circumferences, fasting plasma glucose (FPG) and hemoglobin A(1c). Data were analyzed using stepwise multiple linear regression. RESULTS:: REE, corrected for weight, fat-free mass, age and gender, was significantly greater with FPG>10 mmol/l (P=0.017) and correlated with FPG (P=0.013) and hemoglobin A(1c) as percentage upper limit of normal (P=0.02). Weight was the main determinant of REE. Together with hip circumference and FPG, it explained 81% of the variation. FPG improved the predictability of the equation by >3%. With poor glycemic control, it can represent an increase in REE of up to 8%. CONCLUSION:: Our data indicate that in a population of obese subjects with type 2 diabetes mellitus, REE is better predicted when fasting plasma glucose is included as a variable. doi:10.1038/sj.ijo.0802178

作 者：

Gougeon R；Lamarche M；Yale JF；Venuta T

刊 名：

International journal of obesity 

年，卷(期)：

2002V.26(no.12) 

分类号：

 

关键词：

Diabetes Mellitus, Non-Insulin-Dependent  g <3>  restin  Energy Metabolism  糖尿病, 非胰岛素依赖型  能量代谢

正文语种：

eng 

基金项目：