Changes in viral load in people with virological failure who remain on the same HAART regimen.

OBJECTIVES: To assess the rate of change in viral load and CD4 count over time in HIV-infected patients experiencing virological failure on a HAART regimen. DESIGN: Study population included patients from EuroSIDA, a large, multicentre, observationalstudy enrolling HIV-infected patients across Europe. METHODS: Median change in viral load and CD4 count per month were estimated using the viral load and CD4 measurements obtained over a 12-month period after confirmed virological failure between 3and 4 log10 copies/ml in a population of 488 HIV-infected patients who were left on a failing HAART regimen. RESULTS: The estimated median viral load change in our study population was 0.024 log10 copies/ml per month, statistically different from 0 (P=0.0001). In 20.9% of the patients studied viral load showed a tendency to decrease, in 47.8% showed a tendency to increase by a positive rate no higher than 0.04 log10 copies/ml per month and in the remaining 31.3% showed a tendency to increase bya rate greater than 0.04 log10 copies/ml per month. On average, CD4 counts were estimated to remain stable (decrease at a slow rate of about -0.53 cells/microl per month). CONCLUSIONS: In patients that remained on a stable, but virologically failingHAART regimen (with viral load ranging 1000-10000 copies/ml), the viral load over the ensuing 12-month period increased at a relatively slow rate. In contrast, the CD4 count remained stable, possibly because of partial but sustained viral suppressionbelow the viral load natural set-point. The time-course of selecting more replication-competent virus in patients with virological failure remains to be fully clarified.

作 者：

Cozzi Lepri A；Phillips AN；Miller V；Katlama C；Ledergerber B；Vella S；Weber J；Bruun JN；Kirk O；Clotet B；Lundgrens JD

刊 名：

Antiviral therapy 

年，卷(期)：

2003V.8(no.2) 

分类号：

 

关键词：

Viral  Antiretroviral Therapy, Highly Active  Personal failure  regimen

正文语种：

eng 

基金项目：