N-3 polyunsaturated Fatty acids and inflammation in the arterial wall.

Atherosclerosis, leading to cardiovascular disease, is a chronic condition involving a strong inflammatory component. There is evidence that the n-3 polyunsaturated fatty acids (PUFA) present in oily fish and fish oils protect against cardiovasculardisease. While these fatty acids have well-recognised effects on plasma triacylglycerol concentrations, it is likely that they exert beneficial effects through other mechanisms in addition. A large body of evidence suggests that the n-3 PUFA have anti-inflammatory properties, some of which may be manifested in the arterial wall, either directly or indirectly, to modulate the progression of atherosclerosis. This review critically evaluates the evidence for the anti-inflammatory effects of the n-3PUFA in cells and on pathways which have a direct influence on atherogenesis in the arterial wall.

作 者：

Yaqoob P；Calder PC

刊 名：

European journal of medical research 

年，卷(期)：

2003V.8(no.8) 

分类号：

 

关键词：

Fatty Acids  Fatty Acids, Polyunsaturated  Cardiovascular  脂肪酸类

正文语种：

eng 

基金项目：