TGF-beta signaling pathway in pancreatic cancer cells

TGF-beta is a multifunctional cytokine which regulates cell growth, extracellular matrix deposition, cell differentiation, and immunosuppression etc. The signal is mainly mediated through Smad pathway to inhibit epithelial cell growth. In 50% of pancreatic cancer, Smad4/DPC4 gene is deleted or mutated, which might cause pancreatic carcinogenesis and be associated with highly invasive and metastatic character of the disease. On the other hand, TGF-beta signal itself has recently been shown to actin favor of cancer cells, especially in the late phase of tumor progression. In Smad4-inactivated pancreatic cancer cells, TGF-beta signal regulates a number of genes involved in tumor suppression and progression. The regulated genes and signaling pathways of TGF-beta signal should be investigated to obtain an effective therapeutic target molecule for pancreatic cancer.

作 者：

Ijichi H

刊 名：

日本臨牀 

年，卷(期)：

2004V.62(no.7) 

分类号：

 

关键词：

Transforming Growth Factor beta  Malignant neoplasm of pancreas  Psychological suppression  转化生长因子β

正文语种：

jpn 

基金项目：