Coxsackie B virus infection and onset of childhood diabetes.

Infection with Coxsackie B viruses has been linked to insulin-dependent diabetes mellitus. Nine of 14 serum samples (64%) taken from children at the onset of diabetes were positive for enterovirus RNA by PCR. All of the children were under age six, and five were under age three. By contrast, enterovirus sequences were detected in only two of 45 serum samples from appropriate comparison children (4%). Sequences from six of the positive patients showed strong homology with Coxsackie B3 and B4 viruses, and there were some common patterns among the sequences from infected diabetic children. This is evidence for a role for enteroviruses in childhood diabetes.

作 者：

Clements GB；Galbraith DN；Taylor KW

刊 名：

The Lancet 

年，卷(期)：

1995V.346(no.8969) 

分类号：

 

关键词：

Coxsackievirus Infections  Diabetes Mellitus, Insulin-Dependent  Enterovirus B, Human isolation and purification  柯萨奇病毒感染  糖尿病, 胰岛素依赖型

正文语种：

eng 

基金项目：