学术论文

      1,2环己二醇的连续合成工艺研究

      Continuous synthesis of cyclohexanediol in the micro-flow system

      摘要:
      以环己烯为原料,在微反应器中将环氧化反应与水解反应串联制备1,2环己二醇。实验发现,环氧化反应采用双氧水/甲酸体系,而皂化反应采用NaOH催化开环产物水解。在环氧化反应中,当选用HCOOH作为载氧体,n(环己烯)∶n(双氧水)∶n(HCOOH)=1∶2∶8,40℃下在微反应器中反应5 min;在皂化反应中,n(环己烯)∶n( NaOH)为1∶1?5,70℃下反应10 min,所得到的1,2环己二醇的产率高达98?1%。
      Abstract:
      1, 2?cyclohexanediol was synthesized by mixing epoxidation and hydrolysis reaction in the micro?flow system using cyclohexene as the raw material.Hydrogen peroxide/formic acid system was used in the epoxidation reaction,while sodium hydroxide was used as a catalyst in the hydrolysis reaction.With formic acid as oxygen carrier,the optimal results were obtained in the conditions:ratio of cyclohexene to hydrogen peroxide of 1∶2, ratio of hydrogen peroxide to formic acid of 1 ∶4, temperature of 40 ℃, residence time of 5 min,and the best results (98?1%) were observed when the mixture in the epoxidation was treated with 1?5 times the equivalent of sodium hydroxide in 70 ℃ for 10 min.
      Author: SHEN Lei HE Wei FANG Zheng TIAN Qitao GUO Kai
      作者单位: 南京工业大学 生物与制药工程学院 材料化学工程国家重点实验室,江苏 南京,210009
      年,卷(期): 2017, 39(1)
      在线出版日期: 2017年3月7日
      基金项目: 国家自然科学基金( U1463201);江苏省自然科学基金( BK20130913);江苏高校优势学科建设工程