学术论文

      线粒体转录因子A在心血管疾病的研究进展

      Research Progress on Mitochondrial Transcription Factor A in Cardiovascular Disease

      摘要:
      线粒体的功能障碍,目前已成为国内外研究心血管疾病的关注热点.随着对线粒体转录因子A分子机制的研究,发现其与心血管疾病密切相关.现通过对线粒体转录因子A的分子生物学特性、在心血管疾病的作用机制及治疗等相关方面进行综合阐述,进一步探讨其可能作为新的生物学标志物及治疗药物,为临床治疗提供新的思路.
      Abstract:
      Mitochondrial dysfunction has become a research focus on cardiovascular disease at home and abroad .The mitochondrial transcription factor A ( TFAM) is closely associated with cardiovascular disease .This article reviews the molecular biological characteristics of TFAM,cardiovascular disease mechanisms ,and future possible treatment methods .TFAM could used to be as new biological markers and drug to clinical practice in cardiovascular disease .
      作者: 侯维娜 [1] 丁振江 [1] 董文超 [1] HOU Ruitian [2] WANG Ruijuan [2]
      Author: HOU Weina [1] DING Zhenjiang [1] DONG Wenchao [1] HOU Ruitian [2] WANG Ruijuan [2]
      作者单位: 承德医学院附属医院,河北承德,067000 The Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei,China
      刊 名: 心血管病学进展 ISTIC
      年,卷(期): 2017, 38(2)
      分类号: R54
      在线出版日期: 2017年4月11日
      基金项目: 国家自然科学基金