学术论文

      核因子-κB与动脉粥样硬化关系的研究进展

      Research Progress of Nuclear Factor-κB in Atherosclerosis

      摘要:
      动脉粥样硬化是包括心肌梗死在内的多种心血管疾病的病理基础,是全世界死亡的主要原因.炎症始终存在于动脉粥样硬化发生发展的各个阶段,核因子-κB是炎症反应中的一个主要转录因子,在静息状态下,以同源二聚体或异源二聚体的形式存在于胞质中,通过与抑制剂κB相互作用,保持未活化状态.一旦受到细胞外刺激,如应激、细胞因子和自由基等,核因子-κB与抑制剂κB解离并易位到细胞核中.活化的核因子-κB诱导大量基因转录,包括细胞因子、黏附分子、趋化因子和急性期蛋白等.许多核因子-κB的激活剂和核因子-κB调控的基因直接或间接地参与了动脉粥样硬化的过程.现总结核因子-κB与动脉粥样硬化关系的研究进展.
      Abstract:
      Atherosclerosis is the pathological basis of a variety of cardiovascular diseases ,including myocardial infarction ,and is the world's leading cause of death .Inflammation is always in every stage of atherosclerosis development .Nuclear factor-κB ( NF-κB) is a major transcription factor in inflammatory response .In the resting state ,homodimers or heterodimers are present in the cytoplasm and remain unacti-vated by interaction with an inhibitor of NF-κB ( IκB) .Once exposed to extracelllular stimuli ,such as stress ,cytokines and free radicals ,NF-κB and IκB dissociation and translocation to the nucleus .Activation of NF-κB induced a large number of gene transcription ,including cyto-kines,adhesion molecules ,chemokines and acute phase proteins .Many NF-κB activators and NF-κB-regulated genes directly or indirectly participate in the process of atherosclerosis .In this review,we summarize the progress of the role NF-κB in atherosclerosis.
      作者: 刘倩 [1] 张慧 [1] 林佳乐 [1] 刘琦 [1] 杨阳 [1] HOU Jingbo [2]
      Author: LIU Qian [1] ZHANG Hui [1] LIN Jiale [1] LIU Qi [1] YANG Yang [1] HOU Jingbo [2]
      作者单位: 哈尔滨医科大学附属第二医院,黑龙江哈尔滨,150086 The Second Affiliated Hospital of Harbin Medical University,Harbin 150086,Heilongjiang,China
      刊 名: 心血管病学进展 ISTIC
      年,卷(期): 2017, 38(2)
      分类号: R541.4
      在线出版日期: 2017年4月11日