学术论文

      神经前体细胞表达发育调控蛋白4与盐敏感性高血压

      Neural Precursor Cell Expressed Developmentally Down-regulated 4-Like and Salt-sensitive Hypertension

      摘要:
      原发性高血压是一种主要的心血管危险因素,其发病率高,并会导致一系列严重并发症.该病病因复杂,众多遗传和环境因素共同参与发病.与摄盐有关的高血压被称作盐敏感高血压,无关的则称为盐抵抗高血压,二者在基因水平上具有差异.神经前体细胞表达发育调控蛋白4(NEDD4L)可使上皮细胞钠通道被降解,从而参与血压调节.除去上皮细胞钠通道之外,NEDD4L还与其他肾脏钠通道的调节有关.因而可推知,NEDD4L与盐敏感性高血压密切相关,现对近年来这方面的研究证据进行综述.
      Abstract:
      Primary hypertension is a major cardiovascular risk , which has a high prevalence rate and can cause a series of severe complications .Its etiology is highly complicated with substantial genetic and environmental factors involved .Salt-sensitive hypertension is defined as blood pressure increase related with salt intake , which is regulated by hereditary genetics .Neuronal precursor cell expressed developmentally down regulated-like ( NEDD4L) can degrade the epithelial Na +channels ( ENaC) and consequently participate in blood regulation.Additionally ENaC, NEDD4L also interacts with other sodium channels in the kidney .Therefore, it is speculated that NEDD4L is tightly correlated with salt-sensitive hypertension .This article reviews the latest research in this field .
      作者: 孟庆滔
      Author: MENG Qingtao
      作者单位: 四川大学华西医院心血管内科,四川成都,610041
      刊 名: 心血管病学进展 ISTIC
      年,卷(期): 2017, 38(2)
      分类号: R54
      在线出版日期: 2017年4月11日