学术论文

      丙种球蛋白对新生儿肺炎血清相关免疫指标的影响

      Effect of gamma globulin on serum immune index in neonatal pneumonia

      摘要:
      目的 研究丙种球蛋白对新生儿肺炎血清相关免疫指标的影响.方法 选取新生儿肺炎患儿100例,按随机数字表法分为对照组和观察组,每组50例.对照组给予常规治疗;观察组给予常规治疗联合丙种球蛋白治疗.比较两组疗效、临床体征消失时间、住院时间及免疫指标.结果 观察组总有效率明显高于对照组[96.00%(48/50)比72.00%(36/50)],差异有统计学意义(χ2=10.71,P<0.01).观察组咳嗽消失时间、湿啰音消失时间、口周发绀消失时间、发热消失时间和住院时间均明显短于对照组[(4.39±1.46)d比(6.32±1.61)d、(4.21±0.93)d比(5.36±1.08)d、(0.83±0.15)d比(1.16±0.22)d、(2.53±1.04)d比(4.47±1.13)d和(7.68±0.87)d比(10.03±1.18)d],差异有统计学意义(P<0.01).观察组治疗后IgG、IgA、IgM、CD4+和CD4+/CD8+明显高于对照组[(10.32±2.86)g/L比(6.88±0.83)g/L、(1.14±0.13)g/L比(0.91±0.25)g/L、(0.94±0.21)g/L比(0.85±0.27)g/L、0.516±0.068比0.385±0.063和1.89±0.35比1.57±0.33],而CD8+明显低于对照组(0.303±0.046比0.349±0.048),差异有统计学意义(P<0.05).结论 丙种球蛋白可明显提高新生儿肺炎患儿的疗效,促进各项临床体征恢复,同时也能提高患儿的细胞免疫及体液免疫能力,是一种高效的治疗方案.
      Abstract:
      Objective To study the effect of gamma globulin on serum immune index in neonates with neonatal pneumonia. Methods One hundred neonates with neonatal pneumonia were selected, and they were divided into control group and observation group by random digits table method with 50 cases each. The control group was treated with conventional treatment, and the observation group was treated with conventional treatment combined with gamma globulin. The treatment efficacy, various signs disappearing times, length of stay in hospital and immune indexes were compared between 2 groups.Results The total effective rate in observation group was significantly higher than that in control group:96.00% (48/50) vs. 72.00% (36/50), and there was statistical difference (χ2 = 10.71, P<0.01). The disappearing times of cough, crackles, perioral cyanosis and fever and the length of stay in hospital in observation group were significantly shorter than those in control group:(4.39 ± 1.46) d vs. (6.32 ± 1.61) d, (4.21 ± 0.93) d vs. (5.36 ± 1.08) d, (0.83 ± 0.15) d vs. (1.16 ± 0.22) d, (2.53 ± 1.04) d vs. (4.47 ± 1.13) d and (7.68 ± 0.87) d vs. (10.03 ± 1.18) d, and there were statistical differences (P<0.01). The IgG, IgA, IgM, CD4+and CD4+/CD8+levels after treatment in observation group were significantly higher than those in control group: (10.32 ± 2.86) g/L vs. (6.88 ± 0.83) g/L, (1.14 ± 0.13) g/L vs. (0.91 ± 0.25) g/L, (0.94 ± 0.21) g/L vs. (0.85 ± 0.27) g/L, 0.516 ± 0.068 vs. 0.385 ± 0.063 and 1.89 ± 0.35 vs. 1.57 ± 0.33, but the CD8+was significantly lower than that in control group:0.303 ± 0.046 vs. 0.349 ± 0.048, and there were statistical differences (P<0.05). Conclusions The gamma globulin can not only significantly improve the curative effect in neonates with neonatal pneumonia and promote the recovery of the clinical symptoms, but also improve the efficiency of cell immunity and humoral immunity ability. It is a kind of effective treatment.
      作者: 尹绪凤 雷勋明
      Author: Yin Xufeng Lei Xunming
      作者单位: 湖北医药学院附属东风医院儿科, 湖北十堰,442000
      刊 名: 中国医师进修杂志 ISTIC
      年,卷(期): 2017, 40(3)
      在线出版日期: 2017年3月31日