学术论文

      红细胞单采去除术治疗真性红细胞增多症疗效分析

      Curative effect evaluation of erythrocyte separation in the treatment of patients with polycythemia vera

      摘要:
      目的 探讨红细胞单采去除术治疗真性红细胞增多症(PV)的疗效.方法 选取PV患者65例,按治疗方法将患者分为对照组(20例)和观察组(45例),两组均给予口服羟基脲或肌肉注射干扰素等常规药物治疗,观察组联合红血细胞单采去除术治疗.比较两组治疗前后血红蛋白、红细胞压积(HCT)的变化和不良反应发生情况.结果 两组治疗前血红蛋白和HCT比较差异无统计学意义[(196±17)g/L比(182±23)g/L和0.606±0.049比0.578±0.066,P>0.05];观察组治疗后血红蛋白和HCT明显低于对照组[(153±27)g/L比(168±14)g/L和0.490±0.050比0.539±0.054],差异有统计学意义(P<0.05).两组均未出现明显不良反应.结论 红细胞单采去除术治疗真性红细胞增多症效果显著、安全可靠、不良反应小,是PV首选治疗的方法之一.
      Abstract:
      Objective To observe the curative effect of erythrocyte separation in the treatment of patients with polycythemia vera (PV). Methods Sixty- five patients with P- were selected, and the patients were divided into control group (20 cases) and observation group (45 cases) according to the treatment method. All patients of 2 groups were treated with oral hydroxyurea and intramuscular interferon, but the patients of observation group combined with erythrocyte separation. The hemoglobin and hematocrit (HCT) before and after treatment and untoward reaction were compared between 2 groups. Results There were no statistical differences in hemoglobin and HCT before treatment between 2 groups:(196 ± 17) g/L vs. (182 ± 23) g/L and 0.606 ± 0.049 vs. 0.578 ± 0.066, P>0.05. The hemoglobin and HCT levels after treatment in observation group were significantly lower than those in control group:(153 ± 27) g/L vs. (168 ± 14) g/L and 0.490 ± 0.050 vs. 0.539 ± 0.054, and there were statistical differences (P<0.05). There was no obvious untoward reaction in 2 groups. Conclusions Erythrocyte separation is one of first choices for PV. It is safe and effective, and has less obvious untoward reaction.
      作者: 刘海惠 [1] 任赛赛 [1] 陶艳玲 [2] 张颢 [3]
      Author: Liu Haihui [1] Ren Saisai [1] Tao Yanling [2] Zhang Hao [3]
      作者单位: 272000 山东济宁,济宁医学院研究生处;济宁医学院附属医院血液科 济宁医学院附属医院儿科, 山东济宁,272000 济宁医学院附属医院血液科, 山东济宁,272000
      刊 名: 中国医师进修杂志 ISTIC
      年,卷(期): 2017, 40(3)
      在线出版日期: 2017年3月31日
      基金项目: 山东省科技厅项目,山东省人口和计划生育委员会科技计划项目,济宁医学院附属医院博士启动基金项目,Science and Technology Program of Shandong Province, China,Health and Family Planning Commission of Shandong Province,PhD Start-Up Funds From the Affiliated Hospital of Jining Medical University