学术论文

      细胞铁死亡发生与调控机制的研究进展

      Progress in occurrence and development of ferroptosis

      Abstract:
      With the development of modern medical research , it has been found that there are many forms of cell death under lots of physiological or pathological conditions .Among them, necrosis and apoptosis are the 2 main forms of cell death.In recent years, varieties of new cell death patterns, such as autophagy, oncosis and paraptosis, have been discovered.In 2012, Dixon et al first discovered and reported a new form of iron-dependent cell death , ferroptosis.In this review, we try to expound the morphological and biochemical features of ferroptosis and its related diseases in detail , so as to deepen our understanding of cell death , thus providing new ideas for the prevention and treatment of clinically relevant diseases .
      摘要:
      细胞死亡无论在生理还是在病理条件下都是无法避免的重要环节.传统意义上细胞死亡主要分为凋亡(apoptosis)和坏死(necrosis)两大主要类型,但近年来却发现在诸多病理生理情况下亦有自噬(au-tophagy)、胀亡(oncosis)、副凋亡(paraptosis)、焦亡(pyroptosis)等多种方式参与其中.越来越多细胞死亡方式的发现为进一步明确疾病的发生机制以及为研究人员寻找新的疾病治疗方法提供科学的理论依据.2012年Dixon等[1]首次发现并报道了这一新型细胞死亡方式——铁死亡(ferroptosis),其确切机制尚有待深入研究.
      Author: KANG Chuan-jie ZHANG Xiang-tong MA Wei
      作者单位: 哈尔滨医科大学附属第一医院神经外科急诊绿色通道,黑龙江哈尔滨,150001
      刊 名: 中国病理生理杂志 ISTICPKU
      年,卷(期): 2017, 33(3)
      分类号: R363
      在线出版日期: 2017年4月10日
      基金项目: 国家自然科学基金资助项目