学术论文

      Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives

      Abstract:
      In order to probe the effect of C-2(S)-substituted groups in the antibacterial activity, a series of novel C-2(S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for their in vitro antibacterial activity. The results of antibacterial activities indicated that C-2(S)-substituted pleuromutilin derivatives retained appreciable antibacterial activity, and the 2-fluorination compounds 6a and 6b are more potent than the corresponding 2-hydroxylation analogues 7a and 7b.
      Author: Li Qiang Fu [1] Xing Sheng Guo [2] Xin Liu [1] Hui Li He [1] Yu Ling Wang [2] Yu She Yang [1]
      作者单位: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China
      刊 名: 中国化学快报(英文版) ISTICSCI
      年,卷(期): 2010, 21(5)
      分类号: O6
      机标分类号: TQ4 O62
      在线出版日期: 2010年6月30日