学术论文

      原发性肝癌伴门静脉癌栓组织中肌切蛋白的表达及临床意义

      Expression of muscle scinderin in primary hepatocellular carcinoma with portal vein tumor thrombus and its clinical significance

      摘要:
      目的:分析原发性肝癌伴门静脉癌栓组织中肌切蛋白(SCIN)的表达及临床意义。方法选取原发性肝癌伴门静脉癌栓患者共46例,收集所有患者的癌旁组织、肝癌(HCC)组织以及门静脉癌栓(PVTT)组织三种手术标本并进行免疫组化染色,比较其 SCIN 表达结果。所有患者术后随访3年,比较患者半年内复发率及3年内病死率。结果 SCIN 在癌旁组织、HCC 组织和 PVTT 组织中的阳性表达率分别为69.57%、45.65%、23.91%,呈递减趋势;SCIN 阴性患者半年内复发率及3年内病死率分别为85.71%、95.24%,显著高于 SCIN 阳性患者;SCIN 表达水平与肿瘤直径、有无包膜及甲胎蛋白水平密切相关,差异均有统计学意义(χ2=0.000、0.007、0.035,均 P <0.05)。结论原发性肝癌伴发门静脉癌栓患者 SCIN 表达水平较低,能够作为判断原发性肝癌伴发门静脉癌栓患者的预后指标。
      Abstract:
      Objective To analyze the expression of muscle scinderin(SCIN)in primary hepatocellular carci-noma(HCC)with portal vein tumor thrombus (PVTT)and its clinical significance.Methods 46 primary HCC patients with PVTT were selected.All patients'carcinoma adjacent tissues,HCC tissues,PVTT tissues were collected. SCIN expression in three kinds of surgical specimen was detected by immunohistochemical staining,the results were compared.All patients were followed up for three years,the recurrence rate within half a year and 3 -year mortality were compared.Results The positive expression rates of SCIN in carcinoma adjacent tissues,HCC tissues and PVTT tissues were 69.57%,45.65%,23.91%,which showed a decreasing trend.The relapsed within six months and 3 -year mortality rate of the SCIN -negative patients were 85.71%,95.24%,which were significantly higher than those of the SCIN -positive patients.The SCIN expression level was closely related to tumor size,with or without coating and alpha -fetoprotein level,the differences were statistically significant (χ2 =0.000,0.007,0.035,all P <0.05). Conclusion The SCIN expression level in primary HCC patients with PVTT is low,and it can be used as a prognos-tic indicator for primary HCC patients with PVTT.
      作者: 赵海菲
      Author: Zhao Haifei
      作者单位: 杭州市肿瘤医院病理科, 浙江省杭州,310006
      刊 名: 中国基层医药 ISTIC
      年,卷(期): 2017, 24(6)
      在线出版日期: 2017年3月29日