学术论文

      小体积前列腺增生的组织学特点及对患者下尿路症状的影响

      The histologic characteristics of small -size prostatic hyperplasia and the effect on low urinary tract symptoms

      摘要:
      目的:探讨小体积前列腺增生(SBPH)的组织学特点及对患者下尿路症状(LUTS)的影响。方法选取 SBPH 接受经尿道前列腺电切术(TURP)患者154例,术前评估国际前列腺症状评分(IPSS)、生活质量评分(QOL)、尿潴留例数,行 B 超、尿动力学检查和尿道膀胱镜检查,术后标本行病理检查,分析 SBPH 的组织学特点及对患者 LUTS 的影响。结果 SBPH 患者中合并组织学前列腺炎(HP)141例,检出率为91.56%,其中0级13例(8.44%),1级18例(11.69%),2级76例(49.35%),3级47例(30.52%),单纯SBPH 组与 SBPH 合并 HP 组在年龄、IPSS 评分、QOL 评分、最大尿流率(Qmax)、尿潴留例数差异均有统计学意义(t 值或χ2值分别为2.610、6.607、4.925、2.673、4.421,均 P <0.05),而前列腺体积(PV)的比较差异无统计学意义(t =1.652,P >0.05)。结论 SBPH 的病理类型是以间质增生(纤维组织和平滑肌)为主,SBPH大部分合并 HP 的存在,且以中重度为主,炎症分级程度与 LUTS 呈正相关。
      Abstract:
      Objective To investigate the histologic characteristics of small -size prostatic hyperplasia (SBPH)and the effect on low urinary tract symptoms (LUTS).Methods 154 patients with SBPH who received transurethral resection of prostate (TURP) were enrolled,preoperative examinations included the obtainment of International Prostate Symptom Score(IPSS),evaluation of the quality of life(QOL),cases of urinary retention,ultra-sonography,urodynamic examination,and cystoscopy,postoperative pathology specimen analysis was conducted.The histologic characteristics of small -size prostatic hyperplasia(the histology prostatis and the grade of inflammation) and the effect on LUTS were analyzed.Results A total of 141 cases (91.56%)were diagnosed as SBPH with histo-logical prostatitis,13 cases(8.44%)in grade 0,18 cases(11.69%)in grade 1,76 cases(49.35%)in grade 2 and 47 cases(30.52%)in grade 3.There were statistically significant differences among ages,IPSS,QOL,Qmax,cases of urinary retention between the pure SBPH group and SBPH with HP group(t/χ2 =2.610,6.607,4.925,2.673, 4.421,all P <0.05),while there was no statistically significant difference in PV(t =1.652,P >0.05).Conclusion The main pathologic type is stroma hyperplasia(fibrous and smooth muscle)of SBPH,SBPH is mostly complicated with histological prostatitis,which are mostly moderate and severe.The severity of LUTS is positively correlated with the grade of inflammation.
      作者: 董娟 [1] 付海柱 [1] 宋吉顺 [1] 王永传 [2] 王爱法 [1]
      Author: Dong Juan [1] Fu Haizhu [1] Song Jishun [1] Wang Yongchuan [2] Wang Aifa [1]
      作者单位: 寿光市中医医院泌尿外科, 山东省寿光,262700 潍坊市中医院泌尿外科, 山东省潍坊,261000
      刊 名: 中国基层医药 ISTIC
      年,卷(期): 2017, 24(6)
      在线出版日期: 2017年3月29日