学术论文

      脾多肽对慢性肾脏病尿毒症期患者免疫功能的影响

      Effect of lienal polypeptide on immune system in patients with chronic kidney disease (stage CKD5)

      摘要:
      目的:研究脾多肽注射液对慢性肾脏病(CKD)5期(尿毒症期)患者免疫功能的影响。方法选取慢性 CKD 5期行维持性血液透析患者42例和腹膜透析患者22例为研究对象,按照随机数字表法分为观察组(32例)和对照组(32例),患者均接受血液透析或腹膜透析治疗,观察组采用脾多肽治疗,对照组未采用脾多肽治疗。比较两组患者治疗15 d 后的免疫功能指标(CD +3、CD +4、CD +8、CD +4/CD +8)。结果观察组治疗后免疫功能指标分别为 CD +3(58.26±7.90)%、CD +4(34.46±6.45)%、CD +8(25.33±4.47)%、CD +4/CD +8(1.36±0.21),对照组 CD +3(55.64±5.32)%、CD +4(31.79±7.15)%、CD +8(27.52±4.68)%、CD +4/CD +8(1.16±0.18),观察组 CD +3、CD +4、CD +4/CD +8水平均明显高于对照组(t =2.82、1.61、7.06,均 P <0.05),CD +8水平明显低于对照组(t =0.004,P <0.05)。结论脾多肽可以有效改善慢性 CKD 5期患者的免疫功能。
      Abstract:
      Objective To study the effect of lienal polypeptide injection on immune function in patients with chronic kidney disease(stage CKD5,uremia).Methods 42 patients with maintenance hemodialysis and 42 patients with peritoneal dialysis in stage CKD5 phase were selected as the research subjects.According to the digital table,they were randomly divided into observation group and control group,32 cases in each group.All patients were treated with hemodialysis or peritoneal dialysis,the observation group was treated with lienal polypeptide injection,while the con-trol group was treated without lienal polypeptide injection.The immune function index(CD3+,CD4+,CD8+,CD4+/CD8+) were compared between the two groups after treatment for 15 d.Results In the observation group,the immune index after 15 days treatment were CD3+(58.26 ±7.90)%,CD4+(34.46 ±6.45)%,CD8+(25.33 ±4.47)%,CD4+/CD8+(81.36 ±0.21).In the control group,the immune index after 15 days treatment were CD3+(55.64 ±5.32)%,CD4+(31.79 ±7.15)%,CD8+(27.52 ±4.68)%,CD4+/CD8+(1.16 ±0.18).CD3+,CD4+,CD4+/CD8+ levels of the obser-vation group were significantly higher than those of the control group(t =2.820,t =1.610,t =7.060,all P <0.05). The level of CD8+ was significantly lower than that of the control group(t =0.004,P <0.05).Conclusion Lienal polypeptide can effectively improve the immune function of patients with chronic kidney disease (CKD5 stage).
      Author: Zhao Dakui Ding Juan Zhu Meisong
      作者单位: 淮南东方医院集团肿瘤医院肾内风湿科, 安徽省淮南,232033
      刊 名: 中国基层医药 ISTIC
      年,卷(期): 2017, 24(6)
      在线出版日期: 2017年3月29日