学术论文

      血型鉴定及不规则抗体筛查与新生儿溶血病相关性分析

      Correlation analysis between blood typing test,irregular antibody screening of pregnant women and hemolytic disease of newborn

      摘要:
      目的:分析孕妇血型及抗体筛查与新生儿溶血病的相关性。方法测定孕妇的 ABO 血型及Rh(D)血型,筛查不规则抗体。对有黄疸症状的新生儿进行血型血清学和溶血病检测。结果2032例 O 型孕妇,其丈夫为非 O 型;新生儿发生溶血病152例。2032例非 O 型孕妇,发生新生儿溶血病4例。两组差异有统计学意义(χ2=135.4,P <0.01)。RhD 阴性27例,其丈夫均为 RhD 阳性,发生新生儿溶血病5例。检出孕妇血清中存在不规则抗体11例,发生新生儿溶血病4例。结论孕妇的血型及不规则抗体与新生儿发生溶血病密切相关,故孕期检查应将血型鉴定和不规则抗体筛查作为常规项目,预防母婴血型不合导致的新生儿溶血。
      Abstract:
      Objective To analyze the correlation between the blood typing test,irregular antibodies screening of pregnant women and hemolytic disease of newborn(HDN).Methods The ABO blood type and Rh(D)blood type of pregnant women were detected,and the irregular antibodies of pregnant women were screened.The blood type serol-ogy and hemolytic disease were detected in neonates with jaundice.Results In specimens of 2 032 pregnant women with type O blood,their husbands were non -O blood type,after delivery,152 neonates were diagnosed as HDN. Among 2 032 pregnant women with type non -O blood,only 5 neonates were diagnosed as HDN.There was significant difference between the two groups (χ2 =135.4,P <0.01).27 pregnant women with RhD negative type,their hus-bands were RhD positive,after delivery,4 neonates were diagnosed as HDN.Conclusion Pregnant women's blood type and irregular antibody are closely related to neonatal hemolysis disease.So pregnant women's blood type and irregular antibody should be regular project in pregnancy,and so as to prevent neonatal hemolytic anemia caused by blood type of feto -maternal incompatibility.
      作者: 李小红
      Author: Li Xiaohong
      作者单位: 濮阳市妇幼保健院输血科, 河南省濮阳,457000
      刊 名: 中国基层医药 ISTIC
      年,卷(期): 2017, 24(6)
      在线出版日期: 2017年3月29日