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基因组印迹的动态变化与辅助生殖

基因组印迹是一个导致亲代起源特异基因表达的正常过程,具有性别特异性,在生殖细胞发育过程中可擦除和重建.差异甲基化是基因组印迹形成的最重要机制.对基因组印迹在配子发生和早期胚胎发育过程中的动态变化及其与辅助生殖的关系进行综述.

作 者:
周亮 李蓉  
作者单位:
北京大学深圳医院生殖医学科,518036 
刊 名:
国外医学计划生育/生殖健康分册 
英文刊名:
FOREIGN MEDICAL SCIENCES FAMILY PLANNING/REPRODUCTIVE HEALTH FASICLE 
年,卷(期):
2007 26(4) 
分类号:
R71 
关键词:
基因组印迹 知识脉络  DNA甲基化 知识脉络  生殖细胞 知识脉络  辅助生殖 知识脉络 
机标分类号:
R87 R74 
机标关键词:
基因组印迹动态变化发育过程性别特异性早期胚胎生殖细胞配子发生基因表达辅助生殖可擦除甲基化综述重建起源 
基金项目:
广东省名医工程研究项目 
DOI:
 
参考文献(17条)
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  2. Shuman C.Smith AC.Steele L Constitutional UPD for chromosome 11p15 in individuals with isolated hemihyperplasia is associated with high tumor risk and occurs following assisted reproductive technologies 2006(14)
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  4. Haig D.Westoby M An earlier formulation of the genetic conflict hypothesis of genomic imprinting 2006(3)
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  6. Regha K.Latos PA.Spahn L The imprinted mouse Igf2r/Air cluster-a model maternal imprinting system 2006(1-4)
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  10. Paoloni-Giacobino A Implications of reproductive technologies for birth and developmental outcomes:imprinting defects and beyond 2006(12)
  11. Rossignol S.Steunou V.Chalas C The epigenetic imprinting defect of Beckwith-Wiedemann patients born following assisted reproductive technology is not restricted to the 11P15 region 2006(12)
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  13. Shuman C.Smith AC.Steele L Constitutional UPD for chromosome 11p15 in individuals with isolated hemihyperplasia is associated with high tumor risk and occurs following assisted reproductive technologies 2006(14)
  14. Sato A.Otsu E.Negishi H Aberrant DNA methylation of imprinted loci in superovulated oocytes 2007(1)
  15. Shi W.Haaf T Aberrant methylation patterns at the two-cell stage as an indicator of early developmental failure 2002(3)
  16. Kerjean A.Couvert P.Heams T In vitro follicular growth affects oocyte imprinting establishment in mice 2003(7)
  17. Borghol N.Lornage J.Blachere T Epigenetic status of the H19 locus in human oocytes following in vitro maturation 2006(3)

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