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炎症因子与糖尿病视网膜病变

Inflammatory cytokines and dliabetic retinopathy

近年的研究发现许多炎症因子如C-反应蛋白、白细胞介素、肿瘤坏死因子-α、血浆纤溶酶原激活物抑制因子与糖尿病视网膜病变的发生、发展密切相关.许多药物如非甾体抗炎药、他汀类药物、血管紧张素转换酶抑制剂、血管紧张素Ⅱ受体拮抗剂、噻唑烷二酮类药物均可使炎症因子表达水平下降.

作 者:
江红 匡洪宇 JIANG Hong KUNG Hong-yu  
作者单位:
150001,哈尔滨医科大学附属第一医院内分泌科 
刊 名:
国际内分泌代谢杂志  ISTIC
英文刊名:
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM 
年,卷(期):
2007 27(1) 
分类号:
R77 
关键词:
炎症因子 知识脉络  糖尿病 知识脉络  糖尿病视网膜病变 知识脉络 
机标分类号:
R97 TQ4 
机标关键词:
炎症因子血管紧张素转换酶抑制剂血浆纤溶酶原激活物糖尿病视网膜病变噻唑烷二酮类药物肿瘤坏死因子血管紧张素Ⅱ非甾体抗炎药他汀类药物受体拮抗剂白细胞介素抑制因子反应蛋白表达水平 
基金项目:
黑龙江省科技攻关项目 
DOI:
 
参考文献(22条)
  1. van Hecke MV.Dekker JM.Nijpels G Inflammation and endothelial dysfunction are associated with retinopathy:the Hoom Study 2005
  2. Paseri V.Willerson JT.Yeh ED Direct proinflammatory effect of C-reactive protein on human endothelial cells 2000
  3. Venugopai SK.Devaraj S.Yuhanna L Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells 2002
  4. Joussen AM.Huang S.Poulaki V In vivo retinal gene expression in early diabetes 2001
  5. Joussen AM.Poulaki V.Mitsiades N Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression 2002
  6. Matsumoto K.Sera Y.Ueki Y Comparison of serum concentrations of soluble adhesion molecules in diabetic microangiopathy and macroangiopathy 2002
  7. Mackinnon JR.Knott RM.Forrester JU Altered L-selectin expression in lymphocytes and increased adhesion to endothelium in patients with diabetic retinopathy 2004
  8. Kamiuchi K.Hasegawa G.Obayashi H Intercellular adhesionmolecule1(ICAM-1) polymorphism is associated with diabetic retinopathy in type 2diabetes mellitus 2002
  9. Kowluru RA.Odenbach S Role of interleukin-1 beta in the development of retinopathy in rats:effect antioxidants 2004
  10. Doganay S.Everekliogtu C.Er H Comparison of serum NO,TNFalpha,IL-1beta,sIL-2R,IL-6 and IL-8 levels with grades of retinopathy in patients with diabetes mellitus 2002
  11. Hernandez C.Segura RM.Fonollosa A Interleukin-8,monocyte chemoattractant protein-1 and IL-10 in the vitreous fluid of patients with proliferative diabetic retinopathy 2005
  12. Mohr S Potential new strategies to prevent the development of diabetic retinopathy 2004
  13. Qiao H.Sonoda KH.Sassa Y Abnormal retinal vascular development in IL-18 knockout mice 2004
  14. 匡洪宇.刘丹.邹伟.王月影.崔丽娟 TNF-α值与糖尿病大鼠视网膜病变关系 [期刊论文] -中国糖尿病杂志2001(3)
  15. Sfikakis PP.Markomichelakis N.Theodossiadis GP Regression of sight-threatening macular edema in type 2 diabetes following treatment with the anti-tumor necrosis factor monoclonal antibody infliximab 2005
  16. Ben-Mahmud BM.Mann GE.Datti A Tumor necrosis factor-alpha in diabetic plasma increases the activity of core 2 GlcNAc-T and adherence of human leukocytes to retinal endothelial cells:significance of core2 GlcNAc-T in diabetic retinopathy 2004
  17. Shishodia S.Aggarwal BB Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation,suppresses expression of anti-apoptotic gene products,and enhances apoptosis 2004
  18. Yamagishi SI.Inagaki Y.Nakamura K Pigment epithelium-derived factor inhibits TNF-α-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation 2004
  19. Das A.Menicucci G.Giebel S Plasminogen activator inhibitor-1(PAI-1) in early diabetic retinopathy and retinal neovascularization 2005
  20. Mori F.Hikichi T.Nagaoka T Inhibitory effect of losartan,an AT1angiotensin Ⅱ receptor antagonist,on increased leukocyte entrapment in retinal microcirculation of diabetic rats 2002
  21. Murata T.Hata Y.Ishibashi T Response of experimental retinal neovasculariation to thiazolidinediones 2001
  22. Miyahara S.Kiryu J.Yamashiro K Simvastatin inhibits leukocyte accumulation and vascular permeability in the retinas of rats with streptozotocin-induced diabetes 2004

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  2. 田林红.张明.张宏刚.罗晖.张文博.倪安民 糖尿病视网膜病变肿瘤坏死因子-α水平测定及临床意义 [期刊论文] -中国实用眼科杂志2009(2)
  3. 张秀彬 糖尿病性视网膜病变危险因素分析 [期刊论文] -中国现代医生2008(05)

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