首頁 > 期刊首頁 > 國際眼科雜志 > 2007年3期 > 重組組織型纖維蛋白酶原激活劑治療白內障手術后的纖維蛋白膜
重組組織型纖維蛋白酶原激活劑治療白內障手術后的纖維蛋白膜
Recombinant tissue plasminogen activator for treatment of fibrinous membranes after cataract surgery
- doi：
- 摘要：
- 目的:研究重組組織型纖維蛋白酶原激活劑(tPA)對于治療白內障手術后的纖維蛋白膜的作用.方法:選取白內障人工晶狀體植入術后中度至重度纖維蛋白膜15例,行25μg tPA前房注射.同時給與持續的局部激素和睫狀肌麻痹劑治療,以及常規的裂隙燈檢查和眼壓監測.結果:在前房注射tPA的1 5眼中,其中9眼(60.0%)在2h后纖維蛋白膜完全溶解,11眼(73.3%)在1d內完全溶解.3眼內注射tPA幾天后纖維蛋白膜復發.注射tPA 24h后可觀察到前房反應(P=0.54)和角膜水腫(P=0.083)增加.裂隙燈和眼壓檢查未發現明顯的毒副作用.實驗得到預期的穩定結果.結論:前房注射tPA用于治療白內障手術后出現的纖維蛋白膜具有安全有效的作用.由于病例數量較少,需要進一步觀察.
- Abstract：
- AIM: To investigate the efficacy of recombinant tissue plasminogen activator (TPA) for treatment of fibrinous membranes following cataract surgery.METHODS: 25μg of TPA was injected into the anterior chamber of 15 pseudophakic eyes with moderate to severe fibrinous membranes that developed after cataract surgery.Simultaneously, topical corticosteroid and cycloplegic therapy was continued. Routine follow-up included slit lamp examination and intraocular pressure measurement.RESULTS: Injection of the solution of tissue plasminogen activator into anterior chamber of 15 eyes resulted in complete dissolution of the fibrinous membranes in 9 (60.0%)eyes after 2 hours, and 11 (73.3%) eyes within 1 day. In 3eyes, within a few days after injection, fibrinous membrane recurred. Increased anterior chamber reaction (P=0.54) and corneal edema (P =0.083) were seen after 24hours. No evidence of toxicity was observed as measured by slit-lamp biomicroscopy and intraocular pressure. Finally, expectable stable result was obtained in all of the eyes.CONCLUSION: Safety and high efficacy of TPA in the treatment of fibrinous membranes after cataract surgery are confirmed.
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