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重组组织型纤维蛋白酶原激活剂治疗白内障手术后的纤维蛋白膜

Recombinant tissue plasminogen activator for treatment of fibrinous membranes after cataract surgery

目的:研究重组组织型纤维蛋白酶原激活剂(tPA)对于治疗白内障手术后的纤维蛋白膜的作用.方法:选取白内障人工晶状体植入术后中度至重度纤维蛋白膜15例,行25μg tPA前房注射.同时给与持续的局部激素和睫状肌麻痹剂治疗,以及常规的裂隙灯检查和眼压监测.结果:在前房注射tPA的1 5眼中,其中9眼(60.0%)在2h后纤维蛋白膜完全溶解,11眼(73.3%)在1d内完全溶解.3眼内注射tPA几天后纤维蛋白膜复发.注射tPA 24h后可观察到前房反应(P=0.54)和角膜水肿(P=0.083)增加.裂隙灯和眼压检查未发现明显的毒副作用.实验得到预期的稳定结果.结论:前房注射tPA用于治疗白内障手术后出现的纤维蛋白膜具有安全有效的作用.由于病例数量较少,需要进一步观察.

作 者:
Heydar Siatiri Bahram Eshraghi Mohammad Taher Rajabi Firoozeh Rahimi Nasim Siatiri Heydar Siatiri Bahram Eshraghi Mohammad Taher Rajabi Firoozeh Rahimi Nasim Siatiri  
作者单位:
伊朗德黑兰大学眼科研究中心,Farabi眼科医院 
刊 名:
国际眼科杂志  ISTIC
英文刊名:
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 
年,卷(期):
2007 7(3) 
分类号:
R77 
关键词:
组织型纤维蛋白溶解酶原激活剂 知识脉络  纤维蛋白膜 知识脉络  白内障手术 知识脉络  recombinant tissue plasminogen activator 知识脉络  fibrinous membrane 知识脉络  cataract surgery 知识脉络 
机标分类号:
R77 R69 
机标关键词:
重组组织型纤维蛋白膜酶原激活剂治疗白内障手术后cataract surgerytissue plasminogen activatoranterior chamberintraocular pressure前房注射pressure measurement人工晶状体植入裂隙灯睫状肌麻痹剂眼压检查眼压监测眼内注射溶解 
基金项目:
 
DOI:
 
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