Endothelial Nitric Oxide Synthase Traffic Inducer in the Umbilical Vessels of the Patients with Pre-eclampsia

doi：

10.1007/s11596-009-0222-1

Abstract：

The expression of endothelial nitric oxide synthase traffic inducer (NOSTRIN) was examined in the umbilical vessels of the patients with pre-eclampsia (PE) to explore its possible role in the pathogenesis of PE.The NOSTRIN mRNA in umbilical tissues was determined by RT-PCR.The eNOS activity in umbilical vessels was spectrophotometrically detected.NO2-/NO3-,the stable metabolic end products of NO,was measured by using nitrate reductase.RT-PCR showed that the expression level of NOSTRIN was significantly higher in women with PE than in the normal group (P<0.01).The activity of eNOS was significantly decreased in PE group [(12.83±3.61) U/mg] than in normal group [(21.72±3.83) U/mg] (P<0.01).The level of NO2-/NO3- in PE patients (27.53± 7.48) μmol/mg was significantly lower than that of normal group (54.27±9.53) μmol/mg (P<0.01).The significant negative correlation existed between the expression of NOSTRIN and the activity of eNOS in umbilical vessels of women with PE (r=-0.58,P<0.01).It was concluded that the level of NOSTRIN expression was increased in umbilical vessel of women with PE,indicating that it may be involved in the pathogenesis of PE.

作者：
Author：	Wenpei XIANG[1]  Hanping CHEN[2]  Lian HU[1]  Xiaoyan XU[2]
作者單位：	Center of Reproductive Medicine,Institute of Family Planning Research,Tongji Hospital,Tong]i Medical College,Huazhong University of Science and Technology University,Wuhan 430030,China Department of Obstetrics and Gynecology,Tongji Hospital,Tong]i Medical College,Huazhong University of Science and Technology University,Wuhan 430030,China
期 刊：	華中科技大學學報（醫學）（英德文版）   SCI
Journal：	JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY(MEDICAL SCIENCE)
年，卷(期)：	2009, 29(2)
分類號：	R3
Keywords：	OSTRIN    pre-eclampsia    umbilical vessel    eNOS
機標分類號：	O15 O4
機標關鍵詞：	normal group    nitric oxide synthase    negative correlation    women    level    possible role    eNOS    significant    products    mRNA    end
基金項目：