STUDIES ON BLOOD GLUTATHIONE PEROXIDASE PROTEIN LEVEL OF CHILDREN IN KESHAN DISEASE AND KASHIN-BECK DISEASE AREAS

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Abstract：

Objective To oberve the change in blood glutathione peroxidase (GSH-Px) protein levels of residents in the low-selenium (Se) area by contrasting the blood GSH-Px protein level of the children in the Keshan disease area with those in the Kashin-Beck disease and non-endemic areas. Methods GSH-Px protein levels were measured by enzyme-linked immunosorbent assays (ELISA). The Se content and GSH-Px activity were assayed by the 2,3-diaminonaphthalene spectrofluorimetric method and glutathione reductase-coupled method respectively. Results ①The blood Se content and GSH-Px protein level of children in Keshan disease area (Moding) were significantly lower than those in Xi'an non-endemic area, however, there was no significant difference when compared with the low-Se non-endemic area; ②The blood Se content, GSH-Px activity and GSH-Px protein level of children in the Kashin-Beck disease area (Yulin) were significantly lower than those of children in two non-endemic areas and in the Keshan disease area; ③The blood Se content and GSH-Px activity were positively correlated to the GSH-Px protein level respectively. Conclusion These results indicate that the blood GSH-Px protein level is decreased in the low-Se residents. The Se status not only affects the GSH-Px activity but also regulate the GSH-Px protein level.

作者：	譚武紅種曉紅楊占田翟連榜王立新徐光祿
Author：
作者單位：	Institute of Endemic Diseases, Medical School of Xi'an Jiaotong University, Xi'an 710061, China.
期 刊：	西安交通大學學報(英文版)
Journal：	ACADEMIC JOURNAL OF XI'AN JIAOTONG UNIVERSITY
年，卷(期)：	2002, 14(2)
分類號：	Q503
Keywords：	Kashan disease    Kashin-Beck disease    children    glutathione peroxidase protein
機標分類號：	U X17
機標關鍵詞：	KESHAN DISEASE    Keshan disease    glutathione peroxidase
基金項目：