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突触可塑性与长时程增强现象的研究进展

Progress in research of synaptic plasticity and long-term potentiation

长时程增强(LTP)是突触传递功能可塑性的重要表现形式,是研究学习与记忆的细胞模型.长持续LTP(LL-LTP)是进行长时记忆研究的细胞模型.近年来的研究资料表明,静寂突触转化为功能性突触可能是LTP维持的重要机制.LTP形成后,可以因生理性刺激或外源性刺激而出现反转.由于LTP具有可反转性和反转输入通路的特异性,采用特异电刺激干预成瘾记忆,以创建不损伤正常脑功能的特异的"成瘾记忆丧失疗法"是我们追寻的目标.

作 者:
韩太真 Han Taizhen  
作者单位:
西安交通大学医学院生理学教研室,陕西西安,710061 
刊 名:
西安交通大学学报(医学版)  ISTIC PKU
英文刊名:
JOURNAL OF XI'AN JIAOTONG UNIVERSITY(MEDICAL SCIENCES) 
年,卷(期):
2005 26(4) 
分类号:
Q426 
关键词:
突触可塑性 知识脉络  长时程增强 知识脉络  静寂突触 知识脉络  LTP反转 知识脉络  成瘾记忆 知识脉络 
机标分类号:
R76 B84 
机标关键词:
突触可塑性长时程细胞模型成瘾记忆性刺激脑功能学习与记忆重要表现突触传递记忆研究记忆丧失资料表特异性可反转功能性电刺激转化增强外源通路 
基金项目:
中国科学院资助项目 
DOI:
 
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