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创面 创面修复 创面愈合 失衡 应激 抗氧化能力 排除 收集 有序 机体 检索 氧化剂 氧化应激 炎症反应 生理学 稳态 试验研究 重复 重要作用 防御

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首页 > 学术期刊 > 中国组织工程研究与临床康复 > 2007年2期 > 氧化应激与创面愈合

氧化应激与创面愈合

Oxidative stress and wound healing

目的:创面愈合是一个复杂而有序的生物学过程,任何干扰创面愈合调控环节的内源性或外源性不良因素均可影响创面愈合的生物学过程.氧化应激对许多疾病的发展起着重要作用,现就氧化应激与创面愈合的关系做一阐述.资料来源:应用计算机检索Medline2001-01/2006-02关于氧化应激与创面愈合关系的相关文章,检索词为"oxidative stress,antioxidants,reactive oxygen species,wound repair,wound healing,diabetic wound,chronic wound,non-healing wound",限定文章语言种类为English.并于清华同方,重庆维普中文数据库检索2001-01/2006-02关于氧化应激与创面愈合的关系的相关文章,检索词为"氧化应激、抗氧化剂,活性氧,创面修复、创面愈合、糖尿病创面、慢性创面、难愈性创面",限定文章语言种类为中文.资料选择:对资料进行初筛,选择关于氧化应激与创面愈合关系的文献,对部分明显缺少随机对照的试验研究及重复研究进行筛除,并对剩余文献开始查找全文.资料提炼:共收集108篇关于氧化应激与创面愈合关系的文献,32篇纳入综述.排除76篇为明显缺少随机对照的试验研究或重复研究.资料综合:①氧化应激是机体促氧化剂和抗氧化剂稳态失衡,自由基的产生增多,和(或)机体或组织抗氧化能力下降的一种机体状态.过度的氧化应激可导致组织损害,对许多疾病的发展起着重要作用.②在发生氧化应激的过程中,自由基的产生相对增多.正常情况下,自由基反应对于机体防御机制是必要的,自由基的产生和清除保持平衡.③氧化应激与活性氧密切相关,活性氧既有其积极的一面,在一定程度上发挥其重要的生理学作用;当机体或组织不能抵御过度的活性氧,它也将导致组织或细胞损害.④皮肤创面在愈合的过程中产生过多的活性氧及其来源的降解产物.急慢性创面组织中促氧化能力增加,创伤后氧化应激的产生,慢性创面中抗氧化能力有所增加,间接反映氧化应激水平的升高,也反映出创面组织对氧化应激存在代偿和防御机制.⑤创面组织中氧化应激的产生可能与炎症反应密切相关.在创面愈合的炎症阶段,氧化应激作为促氧化剂与抗氧化剂内环境平衡失调而导致的组织损害.结论:在创面愈合的炎症时期以及慢性创面的治疗时应该考虑到氧化应激的存在,抗氧化治疗是一个治疗策略,适时给予抗氧化治疗将有助于创面愈合.

作 者：
杨国志 王润秀 林源 Yang GZ Wang RX Lin Y  
作者单位：
广西医科大学第一附属医院烧伤整形康复中心,广西壮族自治区南宁市,530021 
刊 名：
中国组织工程研究与临床康复  ISTIC PKU
英文刊名：
JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH 
年，卷(期)：
2007 11(2) 
分类号：
R6 
关键词：
氧化性应激 知识脉络  活性氧 知识脉络  伤口愈合 知识脉络  综述文献 知识脉络 
机标分类号：
R68 O6 
机标关键词：
氧化应激创面愈合创面组织慢性创面活性氧抗氧化剂自由基氧化能力资料生物学过程机体组织损害治疗文章语言随机对照试验研究检索防御机制促氧化剂oxygen species 
基金项目：
国家重点基础研究发展计划(973计划) 
DOI：
 
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