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首页 > 学术期刊 > 中国组织工程研究与临床康复 > 2007年24期 > 干细胞治疗糖尿病的研究现状及未来

干细胞治疗糖尿病的研究现状及未来

Progress in stem cell therapy for diabetes mellitus

目的:综述干细胞治疗糖尿病的研究现状及未来发展.资料来源:应用计算机检索Pubmed 2000-01/2006-11有关干细胞治疗糖尿病方面文献,检索词"djabetes mellitus and stem cell not review",限定文章语言种类为English.资料选择:对检索到的干细胞治疗糖尿病相关文献进行整理,选取针对性强文章.同一领域文献则选择近期发表或权威杂志文章.资料提炼:共检索到359篇相关文献,有关胚胎干细胞、胰腺干细胞、造血干细胞、神经干细胞、骨髓基质干细胞在糖尿病方面研究文章50篇,其中29篇符合要求.资料综合:干细胞极强的自我更新能力和多向分化潜能为糖尿病的细胞治疗开辟了新途径,按其发育阶段不同可以将干细胞分为胚胎干细胞和胰腺干细胞、造血干细胞、神经干细胞、骨髓基质干细胞等成体干细胞.干细胞移植是治疗糖尿病的一条新途径.干细胞生成胰岛素分泌细胞前需要经过诱导分化、细胞选择和细胞成熟3个阶段.干细胞治疗糖尿病研究已取得一定进展,部分实验已纠正糖尿病动物的高血糖状态.结论:干细胞定向分化为胰岛β细胞研究为糖尿病患者点燃了新希望,其勿庸置疑的成为治疗糖尿病的最佳种子细胞.

作 者：
秦逸人 刘慧雯 王锦绣 纪红 Qin YR Liu HW Wang JX Ji H  
作者单位：
哈尔滨医科大学组织学与胚胎学教研室,黑龙江省哈尔滨市,150086 
刊 名：
中国组织工程研究与临床康复  ISTIC PKU
英文刊名：
JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH 
年，卷(期)：
2007 11(24) 
分类号：
R394.2 
关键词：
干细胞 知识脉络  糖尿病 知识脉络  综述文献 知识脉络 
机标分类号：
R58 R2 
机标关键词：
骨髓基质干细胞治疗糖尿病diabetes mellitus细胞治疗造血干细胞胰腺干细胞神经干细胞胚胎干细胞资料选择文献检索多向分化潜能糖尿病患者干细胞移植成体干细胞stem cell资料来源种子细胞针对性强诱导分化 
基金项目：
黑龙江省211工程基金 
DOI：
 
参考文献(29条)
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  20. Bonner-Weir Susan.Sharma A Pancreatic stem cells 2002(4)
  21. Han-Tso Lin.Shih-Hwa Chiou.Chung-Lan Kao.Yi-Ming Shyr.Chien-Jen Hsu.Yih-Wen Tarng.Larry L-T Ho.Ching-Fai Kwok.Hung-Hai Ku Characterization of pancreatic stem cells derived from adult human pancreas ducts by fluorescence activated cell sorting [期刊论文] -世界胃肠病学杂志（英文版）2006(28)
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  1. 孙晓晖.王颜刚 干细胞移植定向分化为胰岛β细胞治疗糖尿病 [期刊论文] -中国组织工程研究与临床康复2009(1)

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