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首页 > 学术期刊 > 心血管病学进展 > 2007年1期 > 心脏脂肪变性与肥胖相关性心脏病

心脏脂肪变性与肥胖相关性心脏病

The Relationship Between Adiposity in the Heart and Obesity Related Heart Diseases

肥胖病是心脏病的危险因素,传统观点认为,在肥胖患者中,由于血流动力学异常和脂代谢异常导致的心脏重构是患者易发展为冠状动脉性疾病和心力衰竭的原因.但最近研究发现,脂肪在心脏沉积可以直接损伤心脏,影响左室重建,导致扩张型心肌病.对肥胖动物模型的研究发现,心肌中脂质过度沉积可导致左室肥厚和缺血性、扩张型心肌病.通过基因治疗或药物干预降低心脏的脂质沉积,可以预防肥胖相关性心脏病的发生.临床研究也提示,心肌的脂质含量可以作为肥胖患者心脏病的生物指标,并且可以成为治疗的靶点.但这方面的研究才刚刚开始,有待进一步的研究.

作 者：
杨菊红 冯凭 YANG Ju-hong FENG Pin  
作者单位：
杨菊红,YANG Ju-hong(天津医科大学《国际内分泌代谢杂志》编辑部,天津,300070)
冯凭,FENG Pin(天津医科大学总医院内分泌科,天津,300052) 
刊 名：
心血管病学进展  ISTIC
英文刊名：
ADVANCES IN CARDIOVASCULAR DISEASES 
年，卷(期)：
2007 28(1) 
分类号：
R5 
关键词：
肥胖病 知识脉络  扩张型心肌病 知识脉络  脂毒性 知识脉络  脂肪变性 知识脉络  心脏 知识脉络 
机标分类号：
R5 R28 
机标关键词：
性心脏病脂肪变性肥胖扩张型心肌病血流动力学异常脂质含量患者脂代谢异常左室重建左室肥厚基因治疗直接损伤脂质沉积药物干预心脏重构心力衰竭危险因素生物指标临床研究冠状动脉 
基金项目：
 
DOI：
 
参考文献(32条)
  1. Kenchaiah S.Evans JC.Levy D Obesity and the risk of heart failure 2002(5)
  2. Wilson PW.D′Agostino RB.Sullivan L Overweight and obesity as determinants of cardiovascular risk:The Framingham experience 2002(16)
  3. Montani JP.Carroll JF.Dwyer TM Ectopic fat storage in heart,blood vessels and kidneys in the pathogenesis of cardiovascular diseases 2004(z4)
  4. Unger RH Minireview:Weapons of lean body mass destruction:The role of ectopic lipids in the metabolic syndrome 2003(12)
  5. Shimabukuro M.Koyama K.Lee Y Leptin-or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity 1997(7)
  6. Zhou YT.Grayburn P.Karim A Lipotoxic heart disease in obese rats:Implications for human obesity 2000(4)
  7. Chiu HC.Kovacs A.Ford DA A novel mouse model of lipotoxic cardiomyopathy 2001(7)
  8. Bjorkegren J.Veniant M.Kim SK Lipoprotein secretion and triglyceride stores in the heart 2001(42)
  9. Finck BN.Han X.Courtois M A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy:Modulation by dietary fat content 2003(3)
  10. Yagyu H.Chen G.Yokoyama M Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy 2003(3)
  11. Cheng L.Ding G.Qin Q Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy 2004(11)
  12. Chiu HC.Kovacs A.Blanton RM Transgenic expression of fatty acidtransport protein 1 in the heart causes lipotoxic cardiomyopathy 2005(2)
  13. Nielsen LB.Bartels ED.Bollano E Overexpression of apolipoprotein B in the heart impedes cardiac triglyceride accumulation and development of cardiac dysfunction in diabetic mice 2002(30)
  14. Yokoyama M.Yagyu H.Hu Y Apolipoprotein B production reduces lipotoxic cardiomyopathy:Studies in heart-specific lipoprotein lipase transgenic mouse 2004(6)
  15. Lee Y.Naseem RH.Duplomb L Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice 2004(37)
  16. Dewald O.Sharma S.Adrogue J Downregulation of peroxisome proliferator-activated receptor-alpha gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species and prevents lipotoxicity 2005(3)
  17. Szczepaniak LS.Dobbins RL.Metzger GJ Myocardial triglycerides and systolic function in humans:In vivo evaluation by localized proton spectroscopy and cardiac imaging 2003(3)
  18. Sharma S.Adrogue JV.Golfman L Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart 2004(14)
  19. Ye D.Edwards WD.Rizkalla W Sudden unexpected death in a 31-year-oldman caused by arrhythmogenic right ventricular cardiomyopathy 2005(10)
  20. Lalani AP.Kanna B.John J Abnormal signal-averaged electrocardiogram (SAECG) in obesity 2000(1)
  21. Schaffer JE Lipotoxicity:When tissues overeat 2003(3)
  22. Borradaile NM.Buhman KK.Listenberger LL A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death 2006(2)
  23. Young ME.Laws FA.Goodwin GW Reactivation of peroxisome proliferator-activated receptor alpha is associated with contractile dysfunction in hypertrophied rat heart 2001(48)
  24. Mann DL Tumor necrosis factor-induced signal transduction and left ventricular remodeling 2002(z6)
  25. Iacobellis G.Corradi D.Sharma AM Epicardial adipose tissue:Anatomical,biomolecular and clinical relation to the heart 2005(10)
  26. Iacobellis G.Pistilli D.Gucciardo M Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease 2005(6)
  27. Iacobellis G.Assael F.Ribaudo MC Epicardial fat from echocardio-graphy:A new method for visceral adipose tissue prediction 2003(2)
  28. Iacobellis G.Ribaudo MC.Assael F Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome:A new indicator of cardiovascular risk 2003(11)
  29. Iacobellis G.Leonetti F Epicardial adipose tissue and insulin resistance inobese subjects 2005(11)
  30. Iacobellis G.Ribaudo MC.Zappaterreno A Relation between epicardial adipose tissue and left ventricular mass 2004(8)
  31. Lee Y.Naseem RH.Park BH Alpha-lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice 2006(1)
  32. Shibata R.Sato K.Pimentel DR Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK-and COX-2-dependent mechanisms 2005(10)

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