Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives

doi:
10.1016/j.cclet.2010.01.001
Abstract:
In order to probe the effect of C-2(S)-substituted groups in the antibacterial activity, a series of novel C-2(S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for their in vitro antibacterial activity. The results of antibacterial activities indicated that C-2(S)-substituted pleuromutilin derivatives retained appreciable antibacterial activity, and the 2-fluorination compounds 6a and 6b are more potent than the corresponding 2-hydroxylation analogues 7a and 7b.
作者
Author: Li Qiang Fu[1]    Xing Sheng Guo[2]    Xin Liu[1]    Hui Li He[1]    Yu Ling Wang[2]    Yu She Yang[1]
作者单位
  1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  2. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China
刊 名: 中国化学快报(英文版)   ISTICSCI
Journal: CHINESE CHEMICAL LETTERS
年,卷(期) 2010, 21(5)
分类号 O6
Keywords: Synthesis 知识脉络    Pleuromutilin 知识脉络    C-2(S)-substituted 知识脉络    Antimicrobial activity 知识脉络   
机标分类号 TQ4 O62
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