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人巨细胞病毒感染状态与免疫

Human cytomegalovirus infection and immunity

人巨细胞病毒(human cytomegalovirus,HCMV)是疱疹病毒科β属病毒,基因为双股线性DNA,具有种属特异性[1].发达国家人群HCMV的感染率为40%~60%,而发展中国家几乎达到100%,且多在婴幼儿时期发生[2].由于与人类免疫系统共同进化,HCMV侵入人体后形成多种独立机制逃避免疫系统的追剿,宿主细胞不能清除这部分病毒,使得其在体内潜伏或呈低度增殖,并与宿主保持相对平衡状态,可长期或终身存在于宿主体内[1-3].在机体免疫状态改变后,这种平衡状态常常被打破,病毒占优势,发生HCMV原发感染或潜伏—激活.由于该病毒感染的普遍性、致病的复杂性、体内不同寻常的潜伏及再激活方式,近10年日益受到重视,对其的研究也有突破性进展.笔者就HCMV感染状态与免疫方面的进展综述如下:

作 者:
 
作者单位:
 
刊 名:
中国康复理论与实践  ISTIC
英文刊名:
CHINESE JOURNAL OF REHABILITATION THEORY AND PRACTICE 
年,卷(期):
2005 11(8) 
分类号:
R373.9 
关键词:
人巨细胞病毒   感染   免疫   综述  
机标分类号:
R37 R39 
机标关键词:
人巨细胞病毒感染状态免疫系统相对平衡状态体内宿主细胞种属特异性婴幼儿时期发展中国家状态改变原发感染疱疹病毒进展综述激活方式机体免疫共同进化发达国家独立机制病毒感染普遍性 
基金项目:
安徽省科技攻关项目,教育部科学技术研究项目 
DOI:
 
参考文献(23条)
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  2. Retiere C.Prod' Homme V.Imbert-Marcille BM Generation of cytomegalovirus-specific human T-lymphocyte clones by using autologous B-lymphoblastoid cells with stable expression of pp65 or IE1 proteins:a tool to study the fine specificity of the antiviral response 2000(9)
  3. Billstrom Schroeder MB.Worthen GS Viral regulation of RANTES expression during human cytomegalovirus infection of endothelial cells 2000(9)
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  7. Odeberg J.Soderberg-Naucler C Reduced expression of HLA class Ⅱ molecules and interleukin-10-and transforming growth factor beta1-independent suppression of T-cell proliferation in human cytomegalovirus-infected macrophage cultures 2001(11)
  8. Greijer AE.Verschuuren EA.Dekkers CA Expression dynamics of human cytomegalovirus immune evasion genes US3,US6,and US11 in the blood of lung transplant recipients 2001(3)
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  11. 瘳利民.石炳毅.梁春泉 肾移植术后受者人巨细胞病毒感染与其它机会感染的研究 1995
  12. Zhuravskaya T.Maciejenski JP.Netski DM Spread of human cytomegalovirus (HCMV) after infection of human hematopoietic progenitor cells:model of HCMV latency 1997(6)
  13. Maciejewski JP.St-Jeor SC Human cytomegalovirus infection of human hematopoietic progenitor cells 1999(1-2)
  14. Prosch S.Docke WD.Reinke P Human cytomegalovirus reactivation in bone-marrow-derived granulocyte/monocyte progenitor cells and mature monocytes 1999(5-6)
  15. Hahn G.Jores R.Mocarski ES Cytomegalovirus remains latent in a common precursor of dendritic and myeloid cell 1998(7)
  16. Soderberg-Naucler C.Fishi KN.Nelson JA Reactivation of latent human cytomegalovirus by alogenic stimulation of blood cells from healthy donors 1997(1)
  17. Soderberg-Naucler C.Fish KN.Nelson JA Interferon-gamma and tumor necrosis factor-alpha specifically induce formation of cytomegalovirus-permissive monocyte-derived macrophages that are refractory to the antiviral activity of these cytokines 1997(12)
  18. Soderberg-Naucler C.Fish KN.Nelson JA Reactivation of latent human cytomegalovirus in CD14(+) monocytes is differentiation dependent 2001(16)
  19. Taylor WJ.Sissons P.Sinclair J Induction of endogenous human cytomegalovirus gene expression after differentiation of monocytes from healthy carriers 1994(3)
  20. Minton ET.Tysoe C.Sinclair TH Human cytomegalovirus infection of the monocyte/macrophage lineage in bone marrow 1994(6)
  21. Ibanez CE.Schrie R.Ghazal P Human cytomegalovirus productively infects primary differentiated macrophages 1991(12)
  22. Maciejewski JP.Bruening EE.Donahue RE Infection of mononucleated phagocytes with human cytomegalovirus 1993(2)
  23. Lathey JL.Spector SA Unrestricted replication of human cytomegalovirus in hydrocortisone-treated macrophages 1991(11)

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