高级检索    帮助
  • 贝克曼库尔特商贸(中国)有限公司
  • 第二届中国流感论坛
  • 万方数据诚聘英才
  • 数字图书馆论坛
  • 万方数据中华医学会


相关检索词

浏览历史

肺动脉高压的治疗进展

Advance in Current Treatment of Pulmonary Arterial Hypertension

肺动脉高压是以肺小动脉痉挛、内膜增生与重构为主要特征的一组临床与病理生理综合征,最终导致肺循环阻力进行性增加、右心功能衰竭直至死亡.肺动脉高压传统治疗效果差,不能延缓疾病进程.然而近年来肺动脉高压发病机制研究与选择性作用于肺循环血管舒张药物的研发,已经证实能够改善疾病预后.外科手术与介入治疗尚缺乏临床应用依据,基因治疗在今后较长时间内仍处于临床前研究阶段.肺动脉高压至今尚无理想治疗手段,本文将对各种治疗方法进行评述,侧重药物治疗进展.

作 者:
王增智 刘双 WANG Zeng-zhi LIU Shuang  
作者单位:
100029,北京市,首都医科大学附属北京安贞医院 
刊 名:
中国全科医学  ISTIC PKU
英文刊名:
CHINESE GENERAL PRACTICE 
年,卷(期):
2007 10(9) 
分类号:
R544.16 
关键词:
高血压,肺性 知识脉络  药物疗法 知识脉络  基因疗法 知识脉络 
机标分类号:
R56 R44 
机标关键词:
肺动脉高压右心功能衰竭临床前研究肺循环阻力选择性作用治疗效果治疗手段治疗进展治疗方法应用依据药物血管舒张外科手术内膜增生介入治疗疾病预后疾病进程基因治疗机制研究动脉痉挛 
基金项目:
 
DOI:
 
参考文献(40条)
  1. Badesch DB.Abman SH.Aheam GS Medical therapy for pulmonary arterial hypertension:ACCP evidence-based clinical practice gidelines 2004(zk)
  2. Rich S.Kaufmann E.Levy PS The effect of high doses of calcium-channel blockers on survival in pulmonary hypertension 1992
  3. Fuster V.Steele PM.Edwards WD Primary pulmonary hypertension:natural history and the importance of thrombosis 1984
  4. Ogata M Ohe.Shirato K Effects of a combination therapy of anticoagulant and vasodilator on the long-term prognosis of primary hypertension 1993
  5. Sitbon O.Badech DB.Channick RN Inhaled nitric oxide as a screening agent for safety identifying responders to oral calcium-channel blockers in primary pulmonary hypertension 1998
  6. Sitbon O.Humbert M.Ioos V Who benefits from long term calcium-channel bloker therapy in primary pulmonary hypertension 2003
  7. Barst RJ.Rubin LJ.Long WA A comparison of continuous intravenous epoprostenol(prostacyclin) with conventional therapy for primary pulmonary hypertension 1996
  8. Mclaughlin V.Shillington A.Rich S Survival in primary pulmonary hypertension:the impact of epoprostenol therapy 2002
  9. Mclaughlin VV.Gaine SP.Barst RJ Efficacy and safety of treprostinil:an epoprostenol analog for primary pulmonary hypertension 2003
  10. Tapson VF.Gomberg Maitland M.McLaughlin V Safety and efficacy of IV treprostinilfor pulmonary arterial hypertension:a prospective,multicenter,open-label,12-week trial 2006
  11. Simonneau G.Barst RJ.Galie N Continuous subcutaneous infusion of treprostinil,a prostacyclin analogue,in patients with pulmonary arterial hypertension:a double-blind randomized controlled trial 2002
  12. Okano Y.Yoshioka T.Shimoucht A Orally active prostacyclin analogue in primary pulmonary hypertesion 2002
  13. Nagaya N.Uemastsu M.Okano Y Effect of orally active prostacyclin analogue on survival of outpatients with primary pulmonary hypertension 1999
  14. Galie N.Humbert M.Vachiery JL Effects of beraprost sodium,an oral p rostacyclin analogue,in patients with pulmonary arterial hypertension:a randomized,double blind placebo controlled trial 2002
  15. Barst RJ.McGoon M.McLaugauhlin V Beraprost therapy for pulmonary arterial hypertension 2003
  16. Krause W.Krais Pharmacokinetics and pharmacodynamics of the prostacyclin analogue iloprost in man 1986
  17. Olschewski H.Ghofant HA.Schmehl T Inhaled iloprost to treat severe pulmonary hypertension:an uncontrolled trial 2000
  18. Hoeper MM.Schwarze M.Ehlerding S Long-term treatment of primary pulmonary hypertension with aerosolized iloprost,a prostacyclin analogue 2000
  19. Oschewski H.Simonneau G.Galie N Inhaled iloprost in severe pulmonary hypertension 2002
  20. Kim H.Yung GL.Marsh JJ Endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension 2000
  21. Yamane K Endothelin and collagen vascular disease:a review with special reference to Raynaud′s phenomenon and systemic sclerosis 1994
  22. Giaid A.Yanagisawa M.Langleben D Expression of endothelin-1 in the lungs of patients with pulmonary hypertension 1993
  23. Channick RN.Simonneau G.Sitbon O Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension:a randomised placebo-controlled study 2001
  24. Rubin LJ.Badesch DB.Barst RJ Bosentan therapy for pulmonary arterial hypertension 2002
  25. Barst RJ.Langleben D.Frost A Sitaxsentan therapy for pulmonary arterial hypertension 2004
  26. Beavo JA.Reifsnyder DH Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors 1990
  27. Ahn H.Foster M.Cable M Ca/CaM-stimulated and cGMP-specific phosphodiesterases in vascular and nonvascular tissues 1991
  28. Atz AM.Wessel DL Sildenafil ameliorates effects of inhaled nitric oxide withdrawal 1999
  29. Nazzareno Galie MD.Hossein A.Ghofrani MD Sildenafil citrate therapy for pulmonary arterial hypertension 2005
  30. Walsh Sukys MC.Tyson JE.Wright LL Persistent pulmonary hypertension of the newborn and role of inhaled nitric oxide:practice variation and outcomes 2000
  31. Goldman AP.Delius RE.Deanfield JE Nitric oxide is superior to prostacyclin for pulmonary hypertension after cardiac operations 1995
  32. Macrae DJ.Field D.Mercier JC Inhaled nitric oxide therapy in neonates and children:reaching a European consensus 2004
  33. Nagaya N.Uematsu M.Oya H Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension 2001
  34. Wilkens H.Guth A.Konig J Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension 2001
  35. Humbert M.Barst RG.Robbins IM Combination of bosentan with epoprostenol in pulmonary arterial hypertension:BREATHE-2 2004
  36. 庞昕焱.李卫华.宋惠民.苏润毅.于建华.李跃华.毕研文.李守先 单向活瓣补片在合并重度肺动脉高压的先天性心脏病患者手术治疗中的应用 [期刊论文] -中华医学杂志2004(11)
  37. Rich S.Lam W Atrial septostomy as palliative therapy for refractory pulmonary hypertension 1983
  38. Rothman A.Beltran D.Kriett JW Graded balloon dilation atrial septostomy as a bridge to lung transplantation in pulmonary hypertension 1993
  39. Reichenberger F.Pepke Zaba J.Mcneil K Atrial septostomy in the treatement of severe pulmonary arterial hypertension 2003
  40. Jamieson SW.Kapelanski DP.Sakakibara N Pulmonary thromboendarterectomy.Experience and lesions in1500 cases 2002

更多...

相似文献
相关博文
引证文献(2条) 
  1. 何小梅.赵丽娜.戚国庆.张会军.王军 超声检测腺苷急性血管扩张试验在先天性室间隔缺损合并重度肺动脉高压中的应用 [期刊论文] -疑难病杂志2009(2)
  2. 范文斌.乔建华 先天性心脏病合并肺动脉高压外科治疗的研究进展 [期刊论文] -罕少疾病杂志2009(1)

更多...