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糖尿病胰岛β细胞凋亡病因学机制

"凋亡"一词的原意是"falling off",指在一定的生理和病理条件下,细胞遵循自身的规律按部就班地走向死亡的过程.细胞凋亡是以一种与细胞有丝分裂完全相反的方式来调节细胞群体相对恒定的重要机制.胰岛β细胞凋亡参与了糖尿病的发病过程.

作 者:
陈香 田浩明  
作者单位:
610041,成都,四川大学附属华西医院内分泌科 
刊 名:
中国糖尿病杂志  ISTIC PKU
英文刊名:
CHINESE JOURNAL OF DIABETES 
年,卷(期):
2002 10(3) 
分类号:
R587 
关键词:
 
机标分类号:
R58 R73 
机标关键词:
糖尿病胰岛β细胞凋亡细胞有丝分裂细胞群体发病过程死亡生理恒定规律调节病理 
基金项目:
 
DOI:
 
参考文献(16条)
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  2. Liu CC.Young LHY.Young JD Lymphocyte-mediated cytolysis and disease 1996
  3. O'Brien BA.Harmon Br.Cameron DP Apoptosis is the mode of β-cell death responsible for the development of IDDM in the nonobese diabetic(NOD) mouse 1997(46)
  4. Nakata M.Uto N.Maruyama I Nitric oxide induces apoptosis via Ca2+-dependent processes in the pancreatic beta-cell line MIN6 1999
  5. Yamada K.Ichikawa F.Ishiyama-shigemoto S Essential role of caspase-3 in apoptosis of mouse β-cells transfected with human FAS 1999
  6. Shimabukuro M.Zhou YT.Levi M Fatty acid-induced β celll apoptosis: a link between obesity and diabetes 1998
  7. Maedler K.Spinas GA.Dyntar D Distinct effects of saturated and monounsaturated fatty acids on β-cell turnover and function 2001
  8. Grill V.Bjorklund A Overstimulation and β-cell function 2001(50)
  9. Donath MY.Gross DJ.Cerasi E Hyperglycemia-induced β-cell apoptosis in pancreatic islets of Psammomus Obesus during development of diabetes 1999
  10. Liu K.Paterson AJ.Chin E Glucose stimulated protein modification by O-linked GlcNAc in pancreatic β-cells: linkage of O-linked GlcNAc to β cell death 2000
  11. Federici M.Hribal M.Perego L High glucose causes apoptosis in cultured human pancreatic islets of langerhans 2001
  12. CLARK A.Wells CA.Buley ID Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes 1988(4)
  13. Soeller WC.Janson J.Hart SE Islet amyloid-associated diabetes in obese AVY/a mice expressing human islet amyloid polypeptide 1998
  14. Janson J.Ashley RH.Harrison D The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles 1999
  15. Janciauskiene S.Ahren B Fibrillar islet amyloid polypeptide differentially affects oxidative mechanisms and lipoprotein uptake in correlation with cytotoxicity in two insulin-producing cell lines 2000
  16. Kobayashi T.Nakanishi K.Nakase H In situ characterization of islets in diabetes with a mitochondrial DNA mutation at nucleotide position 3243 1997

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  2. 李克明.马玉霞 2型糖尿病并发症分析 [期刊论文] -中国实用神经疾病杂志2008(03)
  3. 潘琪.朱峰青.张新明.李界平 参附注射液对链脲霉素诱导1型糖尿病大鼠血清氧自由基及其抗氧化功能的影响 [期刊论文] -中华中医药学刊2007(10)
  4. 宋达琳.郭建.康维强 糖尿病并发感染时细胞因子以及胰岛细胞凋亡的变化 [期刊论文] -中国免疫学杂志2006(11)
  5. 潘琪.李界平.马晓业 链脲霉素诱导1型糖尿病大鼠血清氧自由基及其抗氧化功能的变化 [期刊论文] -中国处方药2006(11)
  6. 宋达琳.郭建.梅少平 糖尿病合并感染时肿瘤坏死因子α与胰岛细胞凋亡的相关性 [期刊论文] -中国慢性病预防与控制2005(04)
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