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脂连素——抗糖尿病的新激素

随着研究的进展,现已发现白色脂肪组织不仅具有储存能量的功能,而且是全身较为重要的内分泌器官.它可分泌多种蛋白,包括肿瘤坏死因子-α、瘦素、抵抗素、血管紧张素肽、纤溶酶原激活抑制因子-1、脂连素(adiponectin)等,它们具有细胞因子的一些结构特点,因此统称为"脂肪因子".

作 者:
吴文君 邹大进  
作者单位:
200433,上海,第二军医大学长海医院内分泌科 
刊 名:
中国糖尿病杂志  ISTIC PKU
英文刊名:
CHINESE JOURNAL OF DIABETES 
年,卷(期):
2003 11(2) 
分类号:
R587 
关键词:
 
机标分类号:
R58 R54 
机标关键词:
脂连素抗糖尿病纤溶酶原激活抑制因子肿瘤坏死因子白色脂肪组织血管紧张素内分泌器官脂肪因子细胞因子结构特点储存能量抵抗素瘦素功能蛋白 
基金项目:
 
DOI:
 
参考文献(23条)
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  2. Scherer PE.Williams S.Fogliano M A novel serum protein similar to C1q, produced exclusively in adipocytes 1995
  3. Maeda K.Okubo K.Shimomura I cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1) 1996
  4. Nakano Y.Tobe T.Choi-Miura NH Isolation and characterization of GBP28,a novel gelatin-binding protein purified from human plasma 1996
  5. Hu E.Liang P.Spiegelman BM AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity 1996
  6. Saito K.Tobe T.Minoshima S Organization of the gene for gelatin-binding protein(GBP28) 1999
  7. Arita Y.Kihara S.Ouchi N Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity 1999
  8. Statnick MA.Beavers LS.Conner LJ Decreased expression of apM1 in omental and subcutaneous adipose tissue of humans with type 2 diabetes 2000
  9. Weyer C.Funahashi T.Tanaka S Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia 2001
  10. Yang WS.Lee WJ.Funahashi T Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin 2001
  11. Hotta K.Funahashi T.Bodkin NL Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys 2001
  12. Yamauchi T.Kamon J.Waki H The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity 2001
  13. Berg AH.Combs TP.Du X The adipocyte-secreted protein Acrp30 enhances hepatic insulin action 2001
  14. Maeda N.Takahashi M.Funahashi T PPARgamma ligands increase expression and plasma concentrations of adiponectin,an adipose-derived protein 2001
  15. Moore GB.Chapman H.Holder JC Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice 2001
  16. Fruebis J.Tsao TS.Javorschi S Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice 2001
  17. 张新超 细胞粘附分子在动脉粥样硬化发生发展中的作用 [期刊论文] -中国动脉硬化杂志1999(2)
  18. Ouchi N.Kihara S.Arita Y Novel modulator for endothelial adhesion molecules adipocyte-derived plasma protein adiponectin 1999
  19. Ouchi N.Kihara S.AritaY Adipocyte-derived plasma protein, adiponectin,suppresses lipid accumulation and class a scavenger receptor expression in human monocyte-derived macrophages 2001
  20. Okamoto Y.Arita Y.Nishida M An adipocyte-derived plasma protein,adiponectin,adheres to injured vascular walls 2000
  21. Zoccali C.Mallamaci F.Tripepi G Adiponectin,metabolic risk factors,and cardiovascular events among patients with end-stage renal disease 2002
  22. Yokota T.Oritani K.Takahashi I Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages 2000
  23. Murakami MY.Taniguchi M.Takahashi K Change in expression of GBP28/adiponectin in carbon tetrachloride-administrated mouse liver 2001

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引证文献(2条) 
  1. 陈宽林.周青.王建 不同体块2型糖尿病脂连素水平变化与意义 [期刊论文] -实用糖尿病杂志2008(03)
  2. 陈宽林.周青.王建 2型糖尿病脂联素水平变化的意义及多因素分析 [期刊论文] -右江医学2007(06)

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