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肝细胞核因子4α及1α与糖尿病的关系

肝细胞核因子(HNF)是一类异质的保守转录因子,参与调节肝脏内糖代谢、脂代谢相关基因的表达.HNF在胰岛中也有表达,其家族成员在β细胞胰岛素基因的转录活化、维持胰岛β细胞正常功能及调节糖代谢等方面都起重要的作用.

作 者:
彭姝彬 沈俊 程孟荣 黄青阳  
作者单位:
彭姝彬,程孟荣,黄青阳(430079,武汉,华中师范大学生命科学学院)
沈俊(宜昌市夷陵医院) 
刊 名:
中国糖尿病杂志  ISTIC PKU
英文刊名:
CHINESE JOURNAL OF DIABETES 
年,卷(期):
2007 15(4) 
分类号:
R5 
关键词:
肝细胞核因子4α 知识脉络  肝细胞核因子1α 知识脉络  MODY 知识脉络  糖尿病,2型 知识脉络 
机标分类号:
R97 R58 
机标关键词:
肝细胞核因子脂代谢相关基因胰岛素基因糖代谢胰岛β细胞转录因子转录活化家族成员调节异质功能肝脏 
基金项目:
国家自然科学基金 
DOI:
 
参考文献(21条)
  1. Seufert J.Weir GC.Habener JF Differential expression of the insulin gene transcriptional repressor CCAAT/enhancerbinding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus 1998
  2. Servitja JM.Ferrer J Transcriptional networks controlling pancreatic development and beta cell function 2004
  3. Mangelsdorf DJ.Evans RM The RXR heterodimers and orphan receptors 1995
  4. Suaud L.Formstecher P.Laine B The activity of the activation function 2 of the human hepatocyte nuclear factor 4(HNF-4alpha) is differently modulated by F domains from various origins 1999
  5. Odom DT.Zizlsperger N.Gordon DB Control of pancreas and liver gene expression by HNF transcription factors 2004
  6. Yamagata K.Furuta H.Oda N Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young(MODY1) 1996
  7. Yamagata K.Oda N.Kaisaki PJ Mutations in the hepatocyte nuclear factor-1 alpha gene in maturity-onset diabetes of the young (MODY3) 1996
  8. Hani EH.Suaud L.Boutin P A missense mutation in hepatocyte nuclear factor-4 alpha,resulting in a reduced transactivation activity,in human late-onset non-insulin-dependent diabetes mellitus 1998
  9. Barroso I.Luan J.Middelberg RP Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-Cell function as well as insulin action 2003
  10. Silander K.Mohlke KL.Scott LJ Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes 2004
  11. Love-Gregory LD.Wasson J.Ma J A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an Ashkenazi Jewish population 2004
  12. Damcott CM.Hoppman N.Ott SH Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the 2004
  13. Hansen SK.Rose CS.Glumer C Variation near the hepatocyte nuclear factor (HNF) -4 alpha gene associates with type2 diabetes in the Danish population 2005
  14. Weedon MN.Owen KR.Shields B Common variants of the hepatocyte nuclear factor-4 alpha P2 promoter are associated with type 2 diabetes in the U.K.population 2004
  15. Ek J.Rose CS.Jensen DP The functional Thr130Ile and Va1255Met polymorphisms of the hepatocyte nuclear factor-4 al-pha (HNF4A):gene associations with type 2 diabetes or altered beta-cell function among Danes 2005
  16. Vaxillaire M.Dina C.Lobbens S Effect of common polymorphisms in the HNF4 alpha promoter on susceptibility to type 2 diabetes in the French Caucasian population 2005
  17. Bagwell AM.Bento JL.Mychaleckyj JC Genetic analysis of HNF-4a polymorphisms in Caucasian-American type 2 diabetes 2005
  18. Winckler W.Graham RR.de Bakker PI Association testing of variants in the hepatocyte nuclear factor 4 alpha gene with risk of type 2 diabetes in 7,883 people 2005
  19. Muller YL.Infante AM.Hansen RL Variants in hepatocyte nuclear factor 4 alpha are modestly associated with type 2diabetes in Pima Indians 2005
  20. Weedon MN.Owen KR.Shields B A large-scale association analysis of common variation of the HNF1 alpha gene with type 2 diabetes in the U.K.Caucasian population 2005
  21. Winckler W.Burtt NP.Holmkvist J Association of common variation in the HNF1alpha gene region with risk of type 2 diabetes 2005

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