蘇木的化學成分研究

Chemical constituents from Sappan Lignum

doi：

摘要：

研究蘇木Caesalpinia sappan L.的化學成分.利用溶劑萃取,反復硅膠、凝膠柱色譜和反相硅膠等手段進行分離純化,根據理化性質、波譜數據進行結構鑒定.分離并鑒定了14個化合物,分別為巴西蘇木素(1),蘇木酮B(2),(E)-3-(3,4-dihydroxybenzylidene)-7-hydroxychroman-4-one(3),3-去氧蘇木酮B(4),brazilide A(5),1,7-二羥基(口山)酮(6),槲皮素(7),鼠李素(8),蘇木查耳酮(9),3-去氧蘇木查耳酮(10),butein(11),2,4,5-三羥基苯甲醛(12),3,8,9-trihydroxy-6H-benzo[c]chromen-6-one(13),β-谷甾醇(14).化合物12和13為兩個新天然產物,首次報道了化合物13的碳譜數據.化合物6為首次從豆科 植物中分離得到, 也是云實屬分離得到的第一個汕酮類化合物.

Abstract：

To study the chemical constituents of Sappan Lignum.Chemical constituents were isolated by method of solvent extraction,repeated chromatography with silica gel,Sephadex LH-20,and ODS.The structures were elucidated based on spectroscopic data.Fourteen compounds were isolated and their structures were identified as brazilin (1),sappanone B (2),(E)-3-(3,4-dihydroxybenzylidene)-7-hydroxychroman-4-one (3),3-deoxysappanone B (4),brazilide A (5),euxanthone (6),quercetin (7),rhamnetin (8),sappanchalcone (9),3-deoxysappanchalcone (10),butein (11),2,4,5-trihydroxybenzaldehyde (12),3,8,9-trihydroxy6H-benzo[c]chromen-6-one (13) and ~-sitosterol (14).Compounds 12 and 13 were two new natural compounds,and the 13C NMR data of compound 13 were reported for the first time.Compound 6 was the first xanthone isolated from the genus Caesalpinia.

作者：	陳玉平劉蕾周雨虹溫晶姜勇屠鵬飛
Author：	Yu-Ping Chen  Lei Liu  Yu-Hong Zhou  Jing Wen  Yong Jiang  Peng-Fei Tu
作者單位：	北京大學中,醫藥現代研究中心,北京100083
期 刊：	中國藥學（英文版）
Journal：	JOURNAL OF CHINESE PHARMACEUTICAL SCIENCES
年，卷(期)：	2008, 17(1)
分類號：	R284.1 R284.2
關鍵詞：	蘇木    化學成分    化學分類學
Keywords：	Caesalpinia sappan    Chemical constituents    Chemotaxonomy
機標分類號：	R28 O62
機標關鍵詞：	蘇木素    化學成分    chemical constituents    酮類化合物    spectroscopic data    solvent extraction    波譜數據    查耳酮    新天然產物    羥基苯甲醛    silica gel    method of    溶劑萃取    理化性質    結構鑒定    硅膠    分離純化    柱色譜    鼠李素    槲皮素
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