高级检索    帮助
  • 贝克曼库尔特商贸(中国)有限公司
  • 第二届中国流感论坛
  • 万方数据诚聘英才
  • 数字图书馆论坛
  • 万方数据中华医学会


相关检索词

浏览历史

异种胰岛移植研究进展

对于1型糖尿病(胰岛素依赖型糖尿病),使用胰岛素治疗虽能有效控制血糖,但不能防止其并发症的发生与发展.胰腺移植存在着创伤大、并发症多和供者不足等缺点,而胰岛移植较胰腺移植具有简单、安全、不良反应轻等优点,仅需占胰腺2%的B细胞即可控制血糖.然而,临床同种胰岛移植的开展受到供者严重短缺和移植物排斥反应的限制.异种胰岛来源广泛,特别是猪胰岛,可以解决供者来源短缺的问题.近年来,随着免疫隔离技术和免疫耐受技术的进展,使异种胰岛移植成为可能.

作 者:
邹一丰 吴小剑 何晓生 兰平  
作者单位:
510080,广州,中山大学附属第一医院胃肠胰外科 
刊 名:
中华器官移植杂志  ISTIC PKU
英文刊名:
CHINESE JOURNAL OF ORGAN TRANSPLANTATION 
年,卷(期):
2007 28(3) 
分类号:
R6 
关键词:
 
机标分类号:
R65 R58 
机标关键词:
异种胰岛移植胰岛素依赖型糖尿病胰腺移植控制血糖移植物排斥反应免疫隔离技术并发症胰岛素治疗发生与发展免疫耐受短缺不良反应猪胰岛细胞临床创伤安全 
基金项目:
国家自然科学基金,广东省科学技术基金 
DOI:
 
参考文献(27条)
  1. Iuzzi M.Cornolti R.Plati T Subcutaneous xenotransplantation of bovine pancreatic islets 2005(28)
  2. Ardelli C.Molano RD.Pileggi A Neonatal porcine pancreatic cell clusters as a potential source for transplantation in humans:characterization of proliferation,apoptosis,xenoantigen expression and gene delivery with recombinant AAV 2002(1)
  3. Wright JR.Yang H.Dooley KC Tilapia-A source of hypoxiaresistant islet cells for encapsulation 1998(3)
  4. Leventhal JR.Sun J.Zhang J Evidence that tilapia islets do not express alpha-(1,3)gal:implications for islet xenotransplantation 2004(3)
  5. Pohajdak B.Mansour M.Hrytsenko O Production of transgenic Tilapia with Brockmann bodies secreting[desThrB30]human insulin 2004(4)
  6. Hiraoka K.Trexler A.Fujioka B Optimal temperature in pancreas preservation by the two-layer cold storage method before islet isolation 2001(1-2)
  7. Matsumoto S.Iwanaga Y.Okitsu T Analysis of largescale nonhuman primate islet isolations 2005(2)
  8. Tanioka Y.Tanaka T.Gotoh T Augmentation of tissue ATP level during digestion using preoxygenated perfluorocarbon results in high islet yield-new strategy for islet isolation 2005(1)
  9. Brandhorst D.Iken M.Brendel MD Adaption of neutral protease activity for islet isolation from the long-term two-layer method-stored pig pancreas 2005(1)
  10. Kim SC.Han DJ.Kang CH Experimental islet isolation in porcine pancreas with new enzyme liberase PI 2004(7)
  11. Bucher P.Bosco D.Mathe Z Optimization of neutral protease to collagenase activity ratio for islet of langerhans isolation 2004(4)
  12. 王计辰.李长东.王秀琴.刘岩 细胞免疫在异种胰岛移植排斥反应中的作用 [期刊论文] -中国煤炭工业医学杂志2003(7)
  13. Koulmanda M.Qipo A.Smith RN Pig islet xenografts are resistant to autoimmune destruction by NOD recipients after anti-CD4 treatment 2003(2)
  14. Devos T.Yan Y.Segers C Role of CD4+ and CD8+ T cells in the rejection of heart or islet enografts in recipients with xenotolerance in the innate immune compartment 2005(1)
  15. Prochorov AV.Tretjak SI.Roudenok VV Long-term normalization of diabetes mellitus after xenotransplantation of fetal pancreatic islet cells into the blood stream without immu nosuppresive therapy 2004(9)
  16. Elliott RB.Escobar L.Calafiore R Transplantation of micro-and macroencapsulated piglet islets into mice and mon keys 2005(1)
  17. 张伟杰.郭晖 免疫隔离大鼠胰岛移植治疗小鼠药物性糖尿病的研究 [期刊论文] -华中科技大学学报(医学版)2003(2)
  18. Schaffellner S.Stadlbauer V.Stiegler P Porcine islet cells microencapsulated in sodium cellulose sulfate 2005(1)
  19. Chen AM.Zhou Y.Swenson K Porcine stem cell engraftment and seeding of murine thymus with class Ⅱ + cells in mice expressing porcine cytokines:toward tolerance induction across discordant xenogeneic barriers 2000(12)
  20. Abe M.Qi J.Sykes M Mixed chimerism induces donorspecific T cell tolerance across a highly disparate xenogeneic barrier 2002(10)
  21. Duncan SR.Capetanakis NG.Lawson BR Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival 2002(6)
  22. Nikolic B.Takeuchi Y.Leykin I Mixed hematopoietic chimerism allows cure of autoimmune diabetes through allogeneic tolerance and reversal of autoimmunity 2004(2)
  23. Shi Q.Wang D.Hadley GA Long-term islet graft survival in NOD mice by abrogation of recurrent autoimmunity 2004(9)
  24. Abraham EJ.Kodama S.Lin JC Human pancreatic islet-derived progenitor cell engraftment in immunocompetent mice 2004(3)
  25. Li H.Inverardi L.Molano RD Nonlethal conditioning for the induction of allogeneic chimerism and tolerance to islet allografts 2003(7)
  26. Mai G.Bucher P.Morel P Role of CD40-CD154 pathway in the rejection of concordant and discordant xenogeneic islets 2005(1)
  27. Lehnert AM.Mottram PL.Han W Blockade of the CD28 and CD40 pathways result in the acceptance of pig and rat islet xenografts but not rat cardiac grafts in mice 2001(1)

更多...

相似文献
相关博文